Mesenchymal Stem Cell Therapy for Huntington Disease: A Meta-Analysis

Table 3

Studies employed rotarod test to evaluate MSC therapy for HD models.

Study	HD model	MSC type	Transplantation time	Post-MSC treatment time (week)	Detection method			Experimental			Control			Statistical significance
					Speed(rpm)	Total observation time (min)	Measurement	Mean	SD	Total	Mean	SD	Total
Bayat [12]	3-NP induced	OE-MSCs	7 days after the 3-NP injection	4	4-40	5	Latency to fall	227.72	35.85	5	97.19	48.65	5
Elbaz [17]	3-NP induced	BM-MSCs	1 hour before the first 3-NP injection	2	25	Not specified	Latency to fall	42.5	6.92	6	14.67	3.76	6
Fink [21]	R6/2	UC-MSCs	5-week-old	6	10	1	Latency to fall	17.45	26.42	9	4.06	3.81	12
Im [26]	YAC128	AMSCs	12-month-old	4	4-40	3	Latency to fall	67.15	11.68	7	83.21	5.84	8
Lee [28]	R6/2	AMSCs	8.5-week-old	4	4-40	3	Latency to fall	54.19	6.77	6	33.87	4.84	6
Lin [25]	QA infusion	BM-MSCs	7 days after the 3-NP injection	13	30	2	Latency to fall	81.07	8.65	16	54.7	11.94	9
Linares [19]	N171-82Q	BM-MSCs	8-week-old	8	0-30	5	Latency to fall	157.52	24.12	10	143.9	34.84	10
Rossignol [20]	R6/2	BM-MSCs	5-week-old	6	10	1	Latency to fall	16.46	16.37	7	7.96	6.64	10
Sadan [23]	R6/2	BM-MSCs	4-week-old	10	Not specified	4	Latency to fall	50.67	65.32	6	54	45.86	7
Yu-Taeger [16]	R6/2	BM-MSCs	4-week-old	6	4-40	6	Latency to fall	57.58	50.16	16	32.5	23.46	14

OE-MSCs: olfactory ecto-mesenchymal stem cells; BM-MSCs: bone marrow mesenchymal stem cells; UC-MSCs: mesenchymal stem cells from umbilical cord; AMSCs: mesenchymal stem cells from the amniotic membrane.