Mesenchymal Stem Cell Therapy for Huntington Disease: A Meta-Analysis

Table 7

Cytokines secreted and modulated by MSCs in HD.

First author and publication year	MSC source	MSC-secreted factors	Modulated factors in brain (MSCs group vs. control group)
Bayat 2021 [12]	OE-MSCs	/	TNFα ↓
Elbaz 2019 [17]	BM-MSCs	/	TNFα ↓, FOXP3 ↑, BDNF ↑, NGF -, TrkB -
Yu-Taeger 2019 [16]	BM-MSCs	/	TNFα ↓, IL -6 ↓, CCR5 ↓, PTGER2 ↓, MCP1 ↓, BDNF -, NGF -, VEGF -
Rossignol 2015 [20]	BM-MSCs	BDNF	TNFα -
Fink 2013 [21]	UC-MSCs	BDNF	/
Moraes 2012 [24]	BM-MSCs	/	BDNF -, FGF2 ↑
Sadan 2012 [22, 23]	BM/MSCs (neurotrophic factor secreting)	BDNF, GDNF	/
Lee 2011 [28]	ASCs (in the endothelial growth medium/2 MV)	NGF, BDNF, HGF, FGF2, VEGF, IGF1	/
Im 2010 [25]	ASCs (in the endothelial growth medium/2 MV)	NGF, BDNF, HGF, FGF2, VEGF, IGF1	/

BDNF: brain-derived neurotrophic factor, GDNF: glial cell derived neurotrophic factor, NGF: nerve growth factor, HGF: hepatocyte growth factor, FGF2: fibroblast growth factors-2, VEGF: vascular endothelial growth factor, IGF1: insulin-like growth factors-1, TNFα: tumor necrosis factor-α, FOXP3: forkhead box protein P3, TrkB: tyrosine kinase receptor B, IL-6: interleukin-6, CCR5: C-C chemokine receptor type 5, MCP1: monocyte chemoattractant protein-1, /: not detected, ↓ a trend () of decrease reported by the study, -: no significant differences, ↑: significant () increase, ↓: significant () decrease.