Hypoxia-Elicited Mesenchymal Stem Cell-Derived Small Extracellular Vesicles Alleviate Myocardial Infarction by Promoting Angiogenesis through the miR-214/Sufu Pathway

<div>Hypoxia induces the expression of miR-214 and targets to Sufu. (a) RT-qPCR was applied to access miR-214 level in MSCs after normoxia or hypoxia preconditioning. (b) RT-qPCR was applied to access miR-214 level in sEVs after normoxia, hypoxia precondition, and miR-214 inhibitor transfection. (c) The putative miR-214 binding sequence in the 3<svg height="7.86364pt" id="M29" style="vertical-align:-0.04981995pt" version="1.1" viewbox="-0.0498162 -7.81382 4.53621 7.86364" width="4.53621pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.013,0,0,-0.013,0,0)"><path d="M295 534L291 558C277 573 202 603 180 597L75 72L120 51L295 534Z"></path></g></svg>UTR of human Sufu and rat Sufu. 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Stem Cells International

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Figure 4

Figure 4: Hypoxia-Elicited Mesenchymal Stem Cell-Derived Small Extracellular Vesicles Alleviate Myocardial Infarction by Promoting Angiogenesis through the miR-214/Sufu Pathway 

Figure 4 | Hypoxia-Elicited Mesenchymal Stem Cell-Derived Small Extracellular Vesicles Alleviate Myocardial Infarction by Promoting Angiogenesis through the miR-214/Sufu Pathway 