Research Article
Hypoxia-Elicited Mesenchymal Stem Cell-Derived Small Extracellular Vesicles Alleviate Myocardial Infarction by Promoting Angiogenesis through the miR-214/Sufu Pathway
Figure 5
miR-214 and hedgehog pathway are involved in MSChyp-sEV-mediated biological function of HUVECs. (a) Representative images of tube formation in HUVECs treated with PBS, MSChyp-sEVs, MSChyp(nc)-sEVs, and MSChyp(inhib)-sEVs and quantification of tube length (). (b) Representative images of scratch assay in HUVECs treated with PBS, MSChyp-sEVs, MSChyp(nc)-sEVs, and MSChyp(inhib)-sEVs and quantification of migration (, ). (c, d) RT-qPCR and western blot were performed to access hedgehog pathway-associated gene expression in HUVECs treated with PBS, MSChyp-sEVs, MSChyp(nc)-sEVs, and MSChyp(inhib)-sEVs.
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