Bone Marrow-Derived Mesenchymal Stem Cells and γ-Secretase Inhibitor Treatments Suppress Amyloid-β25–35-Induced Cognitive Impairment in Rat Dams and Cortical Degeneration in Offspring

Figure 13

Effect of treatment with MSCs and GSI-953 on (a) GSK-3β and (b) BDNF concentration in newborn sera of Aβ25–35-induced Alzheimer’s disease dams. Data were analyzed via two-way ANOVA followed by Tukey’s multiple comparison test. Data are expressed as . , , and vs. the saline-injected group. ^#, ^##, and ^### vs. the AD group. ns: nonsignificant ().

(a)

(b)