MAGEB2-Mediated Degradation of EGR1 Regulates the Proliferation and Apoptosis of Human Spermatogonial Stem Cell Lines

Figure 7

Distribution of MAGEB2 in patients with OA and NOA. (a) Distribution of MAGEB2 in SSC of different testicular tissues detected by dual-color immunofluorescence: the green color is MAGEB2 signal, the red color is GFRA1-labeled SSC signal, and the blue color is DAPI-labeled nucleus. Representative images are shown at the top right with partially enlarged details. Scale . (b) Box plots showing the proportion of MAGEB2-positive SSCs in different samples. Each circle in the box plot represents one result, and at least 20 cross-sections of the seminiferous tubule were counted. (c) Western blot detected the expression of MAGEB2 in different testicular samples. (d) The bar graph demonstrated the relative levels of MAGEB2 in different testicular tissues. OA: obstructive azoospermia with normal spermatogenesis. Spg MA: spermatogonia maturation arrest. Spc MA: spermatocyte maturation arrest. HS: hypospermatogenesis. indicates .

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