Stem Cell-Associated Signatures Help to Predict Diagnosis and Prognosis in Ovarian Serous Cystadenocarcinoma

Table 2

Clinical subgroup analysis of the univariate and multivariate Cox regression models.

Characteristics	Total ()	Univariate analysis		Multivariate analysis
		HR (95% CI)	value	HR (95% CI)	value
FIGO stage	374
Stage I and stage II	24	Reference
Stage III	293	2.045 (0.905–4.621)	0.085	1.981 (0.712–5.511)	0.190
Stage IV	57	2.495 (1.057–5.889)	0.037	1.750 (0.599–5.111)	0.306
Primary therapy outcome	307
PD	27	Reference
SD	22	0.441 (0.217–0.895)	0.023	0.440 (0.211–0.918)	0.029
PR	42	0.652 (0.384–1.107)	0.113	0.602 (0.347–1.047)	0.072
CR	216	0.152 (0.093–0.247)	<0.001	0.179 (0.107–0.299)	<0.001
Age	377
≤60	206	Reference
>60	171	1.355 (1.046–1.754)	0.021	1.402 (1.027–1.913)	0.033
Histologic grade	365
G2	45	Reference
G3	320	1.224 (0.827–1.811)	0.313
Tumor status	336
Tumor free	72	Reference
With tumor	264	9.576 (4.476–20.486)	<0.001	9.400 (3.793–23.298)	<0.001
Lymphatic invasion	148
No	48	Reference
Yes	100	1.413 (0.833–2.396)	0.200
PRLR	377
Low	189	Reference
High	188	1.019 (0.787–1.320)	0.885
SLC38A3	377
Low	187	Reference
High	190	0.961 (0.742–1.244)	0.761
INSRR	377
Low	187	Reference
High	190	1.251 (0.965–1.622)	0.091	0.989 (0.722–1.356)	0.946
CSMD2	377
Low	189	Reference
High	188	1.252 (0.966–1.623)	0.090	0.933 (0.680–1.279)	0.665
CBX2	377
Low	188	Reference
High	189	0.739 (0.570–0.958)	0.022	0.938 (0.680–1.293)	0.696
C19orf33	377
Low	187	Reference
High	190	1.151 (0.889–1.491)	0.287