Research Article

Extracellular Vesicles Secreted by TGF-β1-Treated Mesenchymal Stem Cells Promote Fracture Healing by SCD1-Regulated Transference of LRP5

Figure 9

Schematic representation depicts that bone fracture healing is promoted in mice after transplantation with MSCTGF-β1-EVs in vivo. MSCTGF-β1-EV-SCD1 promotes HUVEC proliferation, angiogenesis, and migration by interactions involving LRP5 in vitro. MSCs: mesenchymal stem cells; EVs: extracellular vesicles; HUVECs: human umbilical vein endothelial cells.