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| NCT number | Condition or disease | Status | Phase | Brief summary | Sponsor |
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| NCT03384433 | Cerebrovascular disorders | Unknown status | Phase 1, Phase 2 | Allogenic mesenchymal stem cell-derived exosome in patients with acute ischemic stroke | Isfahan University of Medical Sciences |
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| NCT05813379 | Antiaging | Recruiting | Phase 1, Phase 2 | Mesenchymal stem cells derived exosomes in skin rejuvenation | Isfahan University of Medical Sciences |
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| NCT04544215 | Drug-resistant | Unknown status | Phase 1, Phase 2 | A clinical study of mesenchymal progenitor cell exosomes nebulizer for the treatment of pulmonary infection | Ruijin Hospital |
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| NCT05871463 | Decompensated liver cirrhosis | Recruiting | Phase 2 | Effect of mesenchymal stem cells-derived exosomes in decompensated liver cirrhosis | Research Institute for Gastroenterology and Liver Diseases (RIGLD) |
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| NCT05523011 | Psoriasis | Completed | Phase 1 | Safety and tolerability study of MSC exosome ointment | Paracrine Therapeutics Dermatology Pte. Ltd |
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| NCT04356300 | Multiple organ failure | Not yet recruiting | Not applicable | Exosome of mesenchymal stem cells for multiple organ dysfunction syndrome after surgical repair of acute type A aortic dissection | Fujian Medical University |
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| NCT05261360 | Knee; injury, meniscus (lateral) (medial)/meniscus tear/meniscus lesion/6 more | Recruiting | Phase 2 | Clinical efficacy of exosome in degenerative meniscal injury | Eskisehir Osmangazi University |
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| NCT05499156 | Perianal fistula in patients with Crohn’s disease | Unknown status | Phase 1, Phase 2 | Safety of injection of placental mesenchymal stem cell-derived exosomes for treatment of resistant perianal fistula in Crohn’s patients | Tehran University of Medical Sciences |
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| NCT04276987 | Coronavirus | Completed | Phase 1 | A pilot clinical study on inhalation of mesenchymal stem cells exosomes treating severe novel coronavirus pneumonia | Ruijin Hospital |
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| NCT05808400 | Long COVID-19 syndrome | Recruiting | Early Phase 1 | Safety and efficacy of umbilical cord mesenchymal stem cell exosomes in treating chronic cough after COVID-19 | Huazhong University of Science and Technology |
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| NCT05402748 | Fistula perianal | Recruiting | Phase 1, Phase 2 | Safety and efficacy of injection of human placenta mesenchymal stem cells derived exosomes for treatment of complex anal fistula | Tehran University of Medical Sciences |
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| NCT04313647 | Healthy | Completed | Phase 1 | A tolerance clinical study on aerosol inhalation of mesenchymal stem cells exosomes in healthy volunteers | Ruijin Hospital |
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| NCT05413148 | Retinitis pigmentosa | Recruiting | Phase 2, Phase 3 | The effect of stem cells and stem cell exosomes on visual functions in patients with retinitis pigmentosa | TC Erciyes University |
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| NCT05216562 | SARS-CoV2 infection | Recruiting | Phase 2, Phase 3 | Efficacy and safety of EXOSOME-MSC therapy to reduce hyperinflammation in moderate COVID-19 patients (EXOMSC-COV19) | Dermama Bioteknologi Laboratorium |
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| NCT03437759 | Macular holes | Unknown status | Early Phase 1 | MSC-Exos promote healing of MHs (MSCs) | Tianjin Medical University |
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| NCT04602104 | Acute respiratory distress syndrome | Unknown status | Phase 1, Phase 2 | A clinical study of mesenchymal stem cell exosomes nebulizer for the treatment of ARDS | Ruijin Hospital |
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| NCT04213248 | Dry eye | Recruiting | Phase 1, Phase 2 | Effect of UMSCs derived exosomes on dry eye in patients With cGVHD | Zhongshan Ophthalmic Center, Sun Yat-sen University |
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| NCT05669144 | Myocardial infarction/myocardial ischemia/myocardial stunning | Recruiting | Phase 1, Phase 2 | Cotransplantation of mesenchymal stem cell-derived exosomes and autologous mitochondria for patients candidate for CABG surgery | Tehran University of Medical Sciences |
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| NCT05787288 | COVID-19 pneumonia | Recruiting | Early Phase 1 | A clinical study on the safety and effectiveness of mesenchymal stem cell exosomes for the treatment of COVID-19 | First Affiliated Hospital of Wenzhou Medical University |
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| NCT02138331 | Diabetes mellitus type 1 | Unknown status | Phase 2, Phase 3 | Effect of microvesicles and exosomes therapy on β-cell mass in type I diabetes mellitus (T1DM) | General Committee of Teaching Hospitals and Institutes, Egypt |
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| NCT04173650 | Dystrophic epidermolysis bullosa | Not yet recruiting | Phase 1, Phase 2 | MSC EVs in dystrophic epidermolysis bullosa | Aegle Therapeutics |
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| NCT05354141 | Acute respiratory distress syndrome/ARDS | Recruiting | Phase 3 | Extracellular vesicle treatment for acute respiratory distress syndrome (ARDS) (EXTINGUISH ARDS) | Direct Biologics, LLC |
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| NCT04493242 | COVID-19 ARDS | Completed | Phase 2 | Extracellular vesicle infusion treatment for COVID-19-associated ARDS | Direct Biologics, LLC |
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| NCT04998058 | Bone loss, osteoclastic/bone loss, alveolar/alveolar bone loss/2 more | Not yet recruiting | Phase 1, Phase 2 | Autogenous mesenchymal stem cell culture-derived signaling molecules as enhancers of bone formation in bone grafting | Pontificia Universidade Católica do Rio Grande do Sul |
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| NCT05387278 | COVID-19 acute respiratory distress syndrome/respiratory distress syndrome | Recruiting | Phase 1 | Safety and effectiveness of placental derived exosomes and umbilical cord mesenchymal stem cells in moderate to severe acute respiratory distress syndrome (ARDS) associated with the novel coronavirus infection (COVID-19) | Vitti Labs, LLC |
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| NCT04388982 | Alzheimer disease | Unknown status | Phase 1, Phase 2 | The safety and the efficacy evaluation of allogenic adipose MSC-Exos in patients with Alzheimer’s disease | Ruijin Hospital |
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