Photobiomodulation Can Enhance Stem Cell Viability in Cochlea with Auditory Neuropathy but Does Not Restore Hearing

Figure 6

Reduction of pluripotency in extensively proliferated ES cells transplanted into the cochlea following secondary neurodegeneration. (a) Undifferentiated GFP-mESCs used in combination therapy. OCT4 (red color) was expressed in GFP-mESC prior to SC transplantation in vitro. The state of the cells before transplantation is maintained in an undifferentiated state. (b) Characteristics of GFP-mESCs after SC transplantation for the combination therapy. In abnormal GFP expressed KM-SC-PBM, OCT4, which was expressed before SC transplantation into the cochlea, was disappeared in most of GFP expressing cells of cochlea regions including Rosenthal’s canal, ST, SV after SC transplantation. Scale bar = (a) 20 µM and (b) 100 and 20 µM.

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