Exosomal miR-141-3p from PDLSCs Alleviates High Glucose-Induced Senescence of PDLSCs by Activating the KEAP1-NRF2 Signaling Pathway

Figure 4

PDLSC-Exos attenuate the dysfunction of high glucose-induced senescent human PDLSCs. (a, b) CCK-8 and plate colony formation assays were utilized to detect the ability of PDLSCs to proliferate. Scale bar, 100 μm. Through wound healing (c, d) and transwell experiments (e, f), cell migration was evaluated. Scale bar, 100 μm. (g, h) ALP staining/activity assays. Scale bar, 100 μm. (i, j) Alizarin red staining and quantification of mineralized nodules. Scale bar, 100 μm. (k, l) Oil red O staining and quantification of the adipogenic differentiation capacity of the cells in the three groups. Scale bar, 100 μm. All data are presented as the ( independent observations). , , and . The corresponding control is indicated.

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