Dental Pulp Stem Cells for Bone Tissue Engineering: A Literature Review

Figure 3

Osteogenic differentiation-related signal pathway diagram. The activation of the Wnt signaling pathway leads to the accumulation of β-catenin. TNF-α can enhance the expression of the Wnt signaling pathway agonist SIRT1, thereby activating this pathway and promoting osteogenic differentiation of DPSCs. ERK1/2 pathway regulates phosphatidylserine (PS) and upregulates the expression of related osteogenic genes. P38 MAPK is involved in the regulation of ACE-II-induced proliferation, and actin inhibitor-mediated osteogenesis inhibits adipogenic differentiation. c-Jun N-terminal kinase signaling pathway regulates methionine adenosyltransferase and promotes the expression of osteogenic genes.