SETD4 Confers Cancer Stem Cell Chemoresistance in Nonsmall Cell Lung Cancer Patients via the Epigenetic Regulation of Cellular Quiescence

<div>SETD4 expression in clinical lung cancer specimens is highly associated with advanced-stage disease. Representative IF images of SETD4/TTF-1 (a) from patients with different stages of LUAD and SETD4/p63 (b) from patients with different stages of LUSC. DAPI, nuclear counterstaining. Scale bar, 20 <i>μ</i>m. (c) Statistical analysis of the proportion of SETD4-positive cells in tumor tissues from NSCLC patients at different stages. Statistical comparisons were performed using a two-tailed Student’s <svg height="8.02022pt" id="M19" style="vertical-align:-0.2063999pt" version="1.1" viewbox="-0.0498162 -7.81382 4.54925 8.02022" width="4.54925pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.013,0,0,-0.013,0,0)"><path d="M324 430H196L233 583L223 592L145 529L120 430H54L29 396L31 388H111L56 126C33 15 54 -12 77 -12C137 -12 214 57 250 95L233 119C208 92 155 59 138 59C126 59 120 70 131 125L186 390L298 394L324 430Z"></path></g></svg> test. <span class="nowrap"><svg height="13.532pt" id="M20" style="vertical-align:-3.4295pt" version="1.1" viewbox="-0.0498162 -10.1025 68.0304 13.532" width="68.0304pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.0091,0,0,-0.0091,0,-5.741)"><path d="M486 158C486 177 478 202 466 220C413 228 386 236 336 262C386 288 413 297 466 304C478 323 486 347 485 366C470 376 444 381 422 380C389 338 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NS: no significant. 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Stem Cells International

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Figure 2

Figure 2: SETD4 Confers Cancer Stem Cell Chemoresistance in Nonsmall Cell Lung Cancer Patients via the Epigenetic Regulation of Cellular Quiescence 