SETD4 Confers Cancer Stem Cell Chemoresistance in Nonsmall Cell Lung Cancer Patients via the Epigenetic Regulation of Cellular Quiescence

Figure 5

Transcriptome profile of SETD4-defined qLCSCs and A-qLCSCs. (a) Heatmap of differentially expressed genes (DEGs) between qLCSCs and A-qLCSCs.. (b) Volcano plot of DEGs. The red dots indicate upregulated genes, and the green dots indicate downregulated genes. Gene ontology (GO) and pathway enrichment analysis of upregulated (c) and downregulated DEGs in qLCSCs (d). GSEA showed downregulated expression of genes involved in cell proliferation (e), carbon metabolism (f), and the PI3K-AKT signaling pathway (g) in qLCSCs compared with A-qLCSCs.

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