Platelet-Derived Mitochondria Attenuate 5-FU-Induced Injury to Bone-Associated Mesenchymal Stem Cells

Figure 8

Schematic summary of the process and mechanism of our study. 5-FU induces the apoptosis of BA-MSCs, and platelet-derived mitochondria attenuates 5-FU-induced apoptosis of BA-MSCs. 5-FU chemotherapy can damage mitochondrial dynamics, mitochondrial functions, and expression of hematopoietic regulatory factor genes in BA-MSCs. However, under the treatment of platelet-derived mitochondria, the damage of mitochondria and hematopoietic regulatory function of BA-MSCs was alleviated. Mitochondria marked in pink: healthy mitochondria of BA-MSCs. Mitochondria marked in yellow: slightly damaged mitochondria of BA-MSCs. Mitochondria marked in red: severely damaged mitochondria of BA-MSCs. Mitochondria marked in green: platelet-derived healthy mitochondria.