Molecular Mechanism of Long Noncoding RNA SNHG14 in Osteogenic Differentiation of Bone Marrow-Derived Mesenchymal Stem Cells through the NEDD4L/FOXA2/PCP4 Axis

Figure 8

Mechanism of SNHG14 in OD of BMSCs. Osteogenic induction upregulated SNHG14 expression level in BMSCs, and SNHG14 bound to HuR increases NEDD4L expression, promoted ubiquitination of FOXA2 to inhibit FOXA2 expression, reduced the enrichment level of FOXA2 on the PCP4 promoter, and upregulated PCP4 transcriptional level, consequently promoting OD of BMSCs.