Research Article

hUMSCs Restore Uterine Function by Inhibiting Endometrial Fibrosis via Regulation of the MMP-9/TIMP-1 Ratio in CDDP-Induced Injury Rats

Figure 5

ELISA and immunofluorescent staining of uterine expressions of fibrosis-related, MMP-9, and TIMP-1 proteins. (a) Levels of Collagen I, Collagen III, CTGF, Fibronectin and α-SMA in each group. (b) Immunofluorescent staining of MMP-9 and TIMP-1 expressions in uterine tissues of each group (200x). (c–e) Mean fluorescent intensities as analyzed by ImageJ software. Data are presented as the . . CDDP: cisplatin; Collagen I: Collagen Type I; Collagen III: Collagen Type III; CTGF: connective tissue growth factor; α-SMA: alpha smooth muscle actin; MMP-9: matrix metalloprotein 9; TIMP-1: tissue inhibitor of metalloproteinase-1.
(a)
(b)
(c)
(d)
(e)