Global Single-Cell Sequencing Landscape of Adipose Tissue of Different Anatomical Site Origin in Humans

Figure 3

Associated Ep cell subpopulations in adipose tissue of different anatomical origins. (a) Single-cell atlas showing Ep cell subpopulations. (b) Single-cell atlas showing EP cell subpopulations in abdominal subcutaneous adipose tissue-leg adipose tissue-visceral adipose tissue. (c) Differential abundance of Ep cell subpopulations in abdominal subcutaneous adipose tissue-leg adipose tissue-visceral adipose tissue. (d) Series of single-cell atlases showing markers for specific cell subpopulations. (e) Biological processes are significantly activated by Ep cell subpopulations. (f) Signaling pathways significantly activated by Ep cell subpopulations. (g) Pseudotime analysis demonstrating pseudotime values (left), pseudotime trajectories (middle), and cell stemness (right) of Ep cell subpopulations. (h) Coexpression modules of transcription factors in Ep cells. Identification of regulator modules based on the connection specificity index (CSI) matrix of regulators (left). Representative transcription factors and their binding patterns in the modules (middle). Cell subpopulations in which transcription factors are located (right). (i) Transcription factors that have regulatory effects on Ep cell subpopulations.

(a)

(b)

(c)

(d)

(e)

(f)

(g)

(h)

(i)