Global Single-Cell Sequencing Landscape of Adipose Tissue of Different Anatomical Site Origin in Humans

Figure 4

Associated fibroblast subpopulations in adipose tissue of different anatomical origins. (a) Single-cell atlas showing fibroblast subpopulations. (b) Single-cell atlas showing fibroblast subpopulations in abdominal subcutaneous adipose tissue-leg adipose tissue-visceral adipose tissue. (c) Differential abundance of fibroblast subpopulations in abdominal subcutaneous adipose tissue-leg adipose tissue-visceral adipose tissue. (d) Series of single-cell atlases showing markers for specific cell subpopulations. (e) Biological processes are significantly activated by fibroblast subpopulations. (f) Signaling pathways are significantly activated by fibroblast subpopulations. (g) Pseudotime analysis demonstrating pseudotime values (left), pseudotime trajectories (middle), and cell stemness (right) for fibroblast subpopulations. (h) Coexpression modules of transcription factors in fibroblasts. Identification of regulator modules based on the connection specificity index (CSI) matrix of regulators (left). Representative transcription factors and their binding patterns in the modules (middle). Cell subpopulations where transcription factors are located (right). (i) Transcription factors that have regulatory effects on fibroblast subpopulations.

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