Global Single-Cell Sequencing Landscape of Adipose Tissue of Different Anatomical Site Origin in Humans

Figure 6

Associated preadipocyte subpopulations in adipose tissue of elderly patients with combined chronic refractory trauma. (a) Single-cell atlas showing preadipocyte subpopulations. (b) Single-cell atlas showing preadipocyte subpopulations in abdominal subcutaneous adipose tissue-leg adipose tissue-visceral adipose tissue. (c) Differential abundance of preadipocyte subpopulations in abdominal subcutaneous adipose tissue-leg adipose tissue-visceral adipose tissue. (d) Series of single-cell atlases showing markers for specific cell subpopulations. (e) Biological processes are significantly activated by preadipocyte subpopulations. (f) Signaling pathways are significantly activated by preadipocyte subpopulations. (g) Pseudotime analysis demonstrating pseudotime values (left), pseudotime trajectories (middle), and cell stemness (right) of preadipocyte subpopulations. (h) Coexpression modules of transcription factors in preadipocyte. Identification of regulator modules based on the connection specificity index (CSI) matrix of regulators (left). Representative transcription factors and their binding patterns in the modules (middle). Cell subpopulations where transcription factors are located (right). (i) Transcription factors that have regulatory effects on preadipocyte subpopulations.

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