Identification and Validation of a Necroptosis-Related Prognostic Signature for Kidney Renal Clear Cell Carcinoma

Figure 10

RiskScore and clinical pathology characters synergistically predicted the survival probability of KIRC patients. (a) Eight different risk subgroups were identified. (b) The overall survival among 8 subgroups had significance. (c) Patients in risk subgroups C3, C6, and C8 belong to the high group, while patients in risk subgroups C1, C2, C5, and C7 belong to the low group. (d) The survival status in 8 subgroups had significant differences. (e, f) M stage, age, and RiskScore were independent prognostic indicators, according to univariate and multivariate Cox survival analysis. (g) A prognostic nomogram to anticipate the 1-, 3-, and 5-year OS of KIRC patients using the M stage, age, and RiskScore. (h) The accuracy and robustness of the prognostic nomogram were demonstrated by the calibration curve. (i) The outcome of decision curve analysis (DCA) demonstrated that among clinical factors used in clinical decision-making, the RiskScore acted as the most exact prognostic indicator.

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