Regenerative Potential of Granulation Tissue in Periodontitis: A Systematic Review and Meta-analysis

Figure 4

(a) Periodontitis is an inflammatory disease affecting tooth-supporting tissues. Granulation tissue exists in the periodontal defects of patients with periodontitis and is usually discarded in traditional therapy. (b) Granulation tissue can be partially preserved during surgical periodontal therapy or minimally processed, acting as a reservoir of progenitor cells. (c) Heterogeneous cells derived from granulation tissue should be further researched preclinically prior to application in clinical practice. (d) Stem/progenitor cells isolated from granulation tissue might be a potential substitute source of stem cells for cell-based therapies in regenerative medicine and dentistry. (e) A combination of stem cells and different types of biomaterials might be the trend in future clinical practice.