Umbilical Cord Mesenchymal Stem Cells Overexpressing Heme Oxygenase-1 Promotes Symptoms Recovery in Cystitis Rats by Alleviating Neuroinflammation

Figure 8

Transduced hUMSCs inhibit activity of TLR4/p65/NLRP3 signal pathway in SDH region. (a) Immunofluorescence staining of NLRP3 (red), the arrows were pointing to NLRP3 positive cells. Scale bar = 50 μm. (b–e) Western blot analysis showing that expression level of TLR4, phosphorylation ratio of p65, and NLRP3 were significantly decreased in SDH after HO-1-hUMSCs treatment. All data were calculated as mean (±SEM) (n = 6 per group). , vs. the CYP group, and ^#, ^##, and ^### vs. the hUMSC group.

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