METTL3 Promotes Osteo/Odontogenic Differentiation of Stem Cells by Inhibiting miR-196b-5p Maturation

<div>Knockdown of miR-196b-5p promoted the osteo/odontogenic of SCAPs <i>in vivo</i>. (a) HE staining results showed bone-/dentin-like tissue formation. Scale bar: 100 <i>μ</i>m. B: bone-/dentin-like tissues; HA: hydroxyapatite tricalcium carrier; CT: connective tissue. (b) Quantitative measurement of HE staining results. Immunohistochemical staining and quantitative analysis of DSPP (c, d) and OCN (e, f). Scale bar: 100 <i>μ</i>m. Student’s <span class="inline" id="M19"></span>-test was performed to determine statistical significance. All error bars represent the standard deviation (<span class="inline" id="M20"></span>). <span class="inline" id="M21"></span> and <span class="inline" id="M22"></span>.</div>

Stem Cells International

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Figure 2

Figure 2: METTL3 Promotes Osteo/Odontogenic Differentiation of Stem Cells by Inhibiting miR-196b-5p Maturation 