Human Infrapatellar Fat Pad Mesenchymal Stem Cell-Derived Extracellular Vesicles Inhibit Fibroblast Proliferation by Regulating <i>MT2A</i> to Reduce Knee Arthrofibrosis

<div>IPFSC-EVs inhibited fibroblast proliferation in the inflammatory environment by regulating <i>MT2A</i>. (a) Cell transfection efficiency under fluorescence microscopy. (b and c) Western blot and RT–PCR analyses showing decreased gene and protein expression of <i>MT2A</i> in the virus strain, indicating successful <i>MT2A</i> silencing. (d and e) Western blot and RT–PCR analysis showing the partially reversed tendency of IPFSC-EVs to inhibit <i>CCDN1</i> and <i>PCNA</i> expression after silencing <i>MT2A</i>. (f) EdU cell proliferation assay showing the partially reversed ability of IPFSC-EVs to inhibit DNA synthesis in fibroblasts after silencing <i>MT2A</i>. 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Stem Cells International

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Figure 5

Figure 5: Human Infrapatellar Fat Pad Mesenchymal Stem Cell-Derived Extracellular Vesicles Inhibit Fibroblast Proliferation by Regulating <i>MT2A</i> to Reduce Knee Arthrofibrosis 

Figure 5 | Human Infrapatellar Fat Pad Mesenchymal Stem Cell-Derived Extracellular Vesicles Inhibit Fibroblast Proliferation by Regulating MT2A to Reduce Knee Arthrofibrosis 