Role of Angiogenesis and Its Biomarkers in Development of Targeted Tumor Therapies

Figure 6

siRNA silencing pathway. Once inside the cytoplasm, siRNA is either directly incorporated into RNA-induced silencing complex (RISC) or undergoes a process mediated by Dicer. Upon RISC loading, the passenger strand dissociates, initiating the RNA interference process by cleaving and degrading the target mRNA.