Stem Cells International

The Promise and Therapeutic Potential of Human ES and iPS Cells


Publishing date
15 May 2011
Status
Published
Submission deadline
15 Nov 2010

Lead Editor

1Stem Cell and Regenerative Medicine Int'l, Marlborough, MA 01752, USA

2University of California San Francisco, San Francisco, CA 94143, USA

3Università degli Studi di Napoli Federico II, Santandrea delle Dame, Via de Crecchio 7, 80138, Napoli, Italy

4Stem Cell Group, Bioprocessing Technology Institute, Singapore 138668


The Promise and Therapeutic Potential of Human ES and iPS Cells

Description

A wide spectrum of diseases may be treatable with non-immunogenic transplantable cells: however current cell-based therapies are limited in scope and have almost exclusively relied on autologous and allogeneic cell sources. While proving to be efficacious, donor-limited cells can be difficult to obtain, have inadequate expansion capabilities, and may result in graft-versus-host disease. Due to their inexhaustible capability to expand and wide-ranging differentiation potential, human embryonic stem cells (hESCs) and induced pluripotent stem cells (iPSCs) hold great promise as alternative cell sources for regenerative medicine. They may help treat diseases involving tissue damage such as atherosclerosis, diabetes, and stroke as well as a variety of hematologic and neurologic disorders. However, several hurdles will need to be overcome before hESCs, iPSCs, or their derivatives can be used therapeutically. In the face of rising health care costs and widespread clinical need, hESCs and/or iPSCs may one day provide a cost-effective means for large-scale production of therapeutic cells.

In this special issue, we invite authors to submit original research articles examining any potential clinical application or preclinical study involving hESCs, human iPSCs, or their derivatives. However, articles focusing on the use of other stem cell sources such as human cord blood, bone marrow, placenta, amnion, or adult tissue-derived pluripotent cells are beyond the scope of this issue. Invited topics for original research articles may include both basic and applied scientific studies such as:

  • Novel cell culture systems (e.g., matrices, 3D bioreactors, etc.) for the production of therapeutically useful cells from hESCs and iPSCs
  • Advances in existing differentiation methods, in particular the development of scalable, feeder-free, and/or serum-free stem cell differentiation systems
  • Biochemical, molecular, or genetic in nature relating to pluripotency or differentiation of stem cells
  • Transplantation of hESC/iPSC derivatives into in vivo model systems of disease

A limited number of review articles will also be welcome and should cover a relevant topic such as progress and pitfalls of differentiating hESCs and/or iPSCs into specific cell types; comparative analysis of hESCs versus iPSCs; or safety issues related to their clinical use.

Before submission authors should carefully read over the journal's Author Guidelines, which are located at http://www.hindawi.com/journals/sci/guidelines/. Prospective authors should submit an electronic copy of their complete manuscript through the journal Manuscript Tracking System at http://mts.hindawi.com/ according to the following timetable:


Articles

  • Special Issue
  • - Volume 2011
  • - Article ID 959275
  • - Editorial

The Promise and Therapeutic Potential of Human ES and iPS Cells

Shi-Jiang Lu | Randall J. Lee | ... | Qiang Feng
  • Special Issue
  • - Volume 2011
  • - Article ID 348960
  • - Review Article

Induced Pluripotent Stem Cells in Cardiovascular Medicine

Toru Egashira | Shinsuke Yuasa | Keiichi Fukuda
  • Special Issue
  • - Volume 2011
  • - Article ID 735420
  • - Review Article

In Vitro Differentiation and Maturation of Human Embryonic Stem Cell into Multipotent Cells

Amer Mahmood | Claudio Napoli | Abdullah Aldahmash
  • Special Issue
  • - Volume 2011
  • - Article ID 212487
  • - Review Article

Patient-Specific Pluripotent Stem Cells in Neurological Diseases

Serpen Durnaoglu | Sermin Genc | Kursad Genc
  • Special Issue
  • - Volume 2011
  • - Article ID 207230
  • - Research Article

Human Motor Neuron Progenitor Transplantation Leads to Endogenous Neuronal Sparing in 3 Models of Motor Neuron Loss

Tanya J. Wyatt | Sharyn L. Rossi | ... | Hans S. Keirstead
  • Special Issue
  • - Volume 2011
  • - Article ID 765378
  • - Research Article

Derivation of Two New Human Embryonic Stem Cell Lines from Nonviable Human Embryos

Svetlana Gavrilov | Darja Marolt | ... | Virginia E. Papaioannou
  • Special Issue
  • - Volume 2011
  • - Article ID 424986
  • - Review Article

Stem Cell-Based Approaches for the Treatment of Diabetes

Catriona Kelly | Cara C. S. Flatt | Neville H. McClenaghan
  • Special Issue
  • - Volume 2011
  • - Article ID 383709
  • - Review Article

Cardiac Differentiation of Pluripotent Stem Cells

Kristiina Rajala | Mari Pekkanen-Mattila | Katriina Aalto-Setälä
  • Special Issue
  • - Volume 2011
  • - Article ID 273076
  • - Review Article

Potential Clinical Applications for Human Pluripotent Stem Cell-Derived Blood Components

Erin A. Kimbrel | Shi-Jiang Lu
Stem Cells International
 Journal metrics
Acceptance rate45%
Submission to final decision76 days
Acceptance to publication40 days
CiteScore3.800
Impact Factor3.902
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