Stem Cells International

The Stem Cell Niche: Interactions between Stem Cells and Their Environment


Publishing date
18 Aug 2017
Status
Published
Submission deadline
31 Mar 2017

Lead Editor
Guest Editors

1University of Edinburgh, Edinburgh, UK

2King’s College London, London, UK

3Karolinska Institute, Stockholm, Sweden


The Stem Cell Niche: Interactions between Stem Cells and Their Environment

Description

Stem cells constitute a source of self-renewing cells with a potential for differentiation into multiple cell lineages. In the embryo, these cells supply the cell lineages that specify different tissues. Adult tissues retain stem cell types with tissue-specific capabilities for tissue turnover and repair. Embryonic and haematopoietic stem cell research has shown that stem cell fates are controlled by their surrounding microenvironment, referred to as the stem cell niche. The niche is formed by the ensemble of stromal cells and the components they produce, including adhesive signals, soluble factors, and matrix proteins. While we have some understanding of the interactions between adult stem cells and their environment, the requisite components of the stem cell niche are still unclear. Furthermore, tissue specific stem cells are likely to reside in specialized niches that require further characterisation. Progress towards understanding and building a stem cell niche will be necessary to advance in situ applications of in vitro reprogrammed cells, differentiated embryonic stem cells, and targeted adult stem cell expansion in tissue regeneration. Stem cell niche mechanisms could additionally reveal how abnormal cell microenvironments, for example, the leukaemic stem cell niche, can contribute to cancer initiation and progression.

This special issue is intended to present novel research and concepts that link stem cell function to the in vivo stem cell microenvironment, including research in stem cell niche in vitro models. We welcome submission of high-quality research studies as well as review articles.

Potential topics include but are not limited to the following:

  • The early embryo as a stem cell niche: comparisons of embryonic stem cells to naïve embryonic stem cell states
  • Haematopoietic stem cells in the yolk sac, AGM, liver, and bone marrow niches
  • Mesenchymal stem cells and microenvironment-directed fate changes
  • Tissue-specific adult stem cell niches: similarities and differences
  • Maintaining the stem cell niche: contributions from ECM and cellular interactions
  • Engineering the stem cell niche: mechanical and topological requirements for the niche

Articles

  • Special Issue
  • - Volume 2018
  • - Article ID 4879379
  • - Editorial

The Stem Cell Niche: Interactions between Stem Cells and Their Environment

Sari Pennings | Karen J. Liu | Hong Qian
  • Special Issue
  • - Volume 2018
  • - Article ID 1247857
  • - Review Article

Cardiac Stem Cells in the Postnatal Heart: Lessons from Development

Cristina Aguilar-Sanchez | Melina Michael | Sari Pennings
  • Special Issue
  • - Volume 2018
  • - Article ID 7127042
  • - Research Article

Laminin 521 Stabilizes the Pluripotency Expression Pattern of Human Embryonic Stem Cells Initially Derived on Feeder Cells

Halima Albalushi | Magdalena Kurek | ... | Jan-Bernd Stukenborg
  • Special Issue
  • - Volume 2017
  • - Article ID 9841035
  • - Research Article

Extracellular Vesicles from Adipose-Derived Mesenchymal Stem/Stromal Cells Accelerate Migration and Activate AKT Pathway in Human Keratinocytes and Fibroblasts Independently of miR-205 Activity

Andrea da Fonseca Ferreira | Pricila da Silva Cunha | ... | Dawidson Assis Gomes
  • Special Issue
  • - Volume 2017
  • - Article ID 9275248
  • - Research Article

Effect of Isolation Technique and Location on the Phenotype of Human Corneal Stroma-Derived Cells

Richárd Nagymihály | Zoltán Veréb | ... | Goran Petrovski
  • Special Issue
  • - Volume 2017
  • - Article ID 2057168
  • - Research Article

Comparing Circadian Dynamics in Primary Derived Stem Cells from Different Sources of Human Adult Tissue

Eve H. Rogers | Sandra A. Fawcett | ... | John A. Hunt
  • Special Issue
  • - Volume 2017
  • - Article ID 6406025
  • - Review Article

Remodeling the Human Adult Stem Cell Niche for Regenerative Medicine Applications

Silvana Bardelli | Marco Moccetti
  • Special Issue
  • - Volume 2017
  • - Article ID 7471582
  • - Review Article

Cardiac Progenitor Cells and the Interplay with Their Microenvironment

Arianna Mauretti | Sergio Spaans | ... | Carlijn V. C. Bouten
  • Special Issue
  • - Volume 2017
  • - Article ID 5046953
  • - Review Article

Structure and Functions of Blood Vessels and Vascular Niches in Bone

Saravana K. Ramasamy
  • Special Issue
  • - Volume 2017
  • - Article ID 2348485
  • - Research Article

Insulin-Like Growth Factor Binding Protein-6 Alters Skeletal Muscle Differentiation of Human Mesenchymal Stem Cells

Doaa Aboalola | Victor K. M. Han
Stem Cells International
 Journal metrics
Acceptance rate45%
Submission to final decision76 days
Acceptance to publication35 days
CiteScore3.800
Impact Factor3.902
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