Stem Cells International

Microenvironmental Cues for Stem Cell Fate Determinants


Publishing date
01 May 2022
Status
Closed
Submission deadline
07 Jan 2022

Lead Editor

1Army Medical University, Chongqing, China

2Huazhong University of Science and Technology, Wuhan, China

3Zhejiang University, Hangzhou, China

4University of Bern, Bern, Switzerland

This issue is now closed for submissions.
More articles will be published in the near future.

Microenvironmental Cues for Stem Cell Fate Determinants

This issue is now closed for submissions.
More articles will be published in the near future.

Description

In adults, tissue-specific stem cells are responsible for the replacement of differentiated cells within continuously regenerating tissues. In the past decade, they have attracted increasing attention and are now widely used in the field of regenerative medicine. Utilizing the self-renewal ability and differentiation attributes of stem cells, numerous tissues could be regenerated by a stem cell-based approach. For example, tissue engineering strategies based on stem cells exhibit promising potential for the regeneration of intervertebral discs, which was previously regarded as a non-repairing tissue. Therefore, it is important to regulate stem cells to realize their maximum regenerative efficiency.

Recent studies have shown the fate of stem cells may be significantly more dynamic than previously appreciated, including self-renewal, differentiation, death, migration, and adhesion. Numerous factors control and manipulate the cellular microenvironment to direct the fate of stem cells. These include physical, biochemical, and cell-cell interactions, as well as other factors in the microenvironment. It is essential to have a comprehensive understanding of the determinants of stem cell fate in the microenvironment so that we can better apply therapeutic strategies with precise control of specific microenvironmental characteristics to best regulate cells to promote tissue regeneration.

This Special Issue, therefore, invites contributions of both original research and review articles reporting recent efforts in the study and development of stem cell fate determinants in the microenvironment.

Potential topics include but are not limited to the following:

  • Microenvironmental physics that regulate stem cell fate
  • Microenvironmental biochemical factors that regulate stem cell fate
  • Microenvironmental mechanics that regulate stem cell fate
  • Microenvironmental intercellular crosstalk in the regulation of stem cell fate
  • Microenvironmental immunomodulation for stem cell fate decisions
  • Tissue microenvironment changes during aging and disease and their impact on the regulation of stem cell fate
  • Bioengineering technology for remodeling the microenvironment with regard to regulating stem cell fate decisions

Articles

  • Special Issue
  • - Volume 2022
  • - Article ID 5014895
  • - Research Article

Adipose-Derived Stem Cells Exosomes Improve Fat Graft Survival by Promoting Prolipogenetic Abilities through Wnt/β-Catenin Pathway

Kexin Chen | Jiachao Xiong | ... | Yuchong Wang
  • Special Issue
  • - Volume 2022
  • - Article ID 8775591
  • - Review Article

Insight in Hypoxia-Mimetic Agents as Potential Tools for Mesenchymal Stem Cell Priming in Regenerative Medicine

Agata Nowak-Stępniowska | Paulina Natalia Osuchowska | ... | Elżbieta Anna Trafny
  • Special Issue
  • - Volume 2022
  • - Article ID 5403995
  • - Review Article

Advances in Regulatory Strategies of Differentiating Stem Cells towards Keratocytes

Aini Zhang | Wei Zhang | ... | Jialin Chen
  • Special Issue
  • - Volume 2021
  • - Article ID 4633270
  • - Review Article

Ginsenoside Rg1 as a Potential Regulator of Hematopoietic Stem/Progenitor Cells

Fang He | Guanping Yao
  • Special Issue
  • - Volume 2021
  • - Article ID 9778207
  • - Research Article

Sox9-Increased miR-322-5p Facilitates BMP2-Induced Chondrogenic Differentiation by Targeting Smad7 in Mesenchymal Stem Cells

Yongsheng Zeng | Chengcheng Du | ... | Chen Zhao
  • Special Issue
  • - Volume 2021
  • - Article ID 9230866
  • - Review Article

Elucidating the Pivotal Neuroimmunomodulation of Stem Cells in Spinal Cord Injury Repair

Seidu A. Richard | Marian Sackey
Stem Cells International
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Article of the Year Award: Outstanding research contributions of 2021, as selected by our Chief Editors. Read the winning articles.