Stem Cells International

Ex Vivo and In Vivo Stem Cells-Based Tissue Engineering Strategies for Their Use in Regenerative Medicine


Status
Published

Lead Editor

1University of Granada, Granada, Spain

2Ghent University, Ghent, Belgium

3Turin University, Turin, Italy


Ex Vivo and In Vivo Stem Cells-Based Tissue Engineering Strategies for Their Use in Regenerative Medicine

Description

Tissue engineering is an emergent discipline which has the aim to elaborate bioartificial tissues or functional substitutes through the rational combination of biomaterials, cells, and growth factors. For years, these bioartificial tissues were elaborated by using adult differentiated cells obtained from healthy biopsies. However, most of these cells are difficult to isolate, showed slow ex vivo expansion, and lose their phenotype and genotype or even worse; some cells are not always available or their use is clinically limited. In this regard, stem cells emerged as a promising cell source for the elaboration of different kinds of bioartificial tissues by tissue engineering. Depending on the linage of these stem cells, they showed an acceptable expansion capability, they are cryopreservable, they can modulate the host immune response, and, finally, under the correct stimuli, they have the extraordinary capability to differentiate into other cells linages by changing their genotype and phenotype. However, much still needs to be elucidated in order to be able to create efficient and safe bioartificial substitutes for clinical use.

We invite researchers to contribute original research articles and reviews focused on the use of different kinds of stem cells as base for the fabrication of three-dimensional (3D) bioartificial substitutes for future clinical applications. Ex vivo studies must be focused on in the design and characterization of these novel stem cells-based 3D substitutes, with special interest in the stem cell behavior and cell-biomaterials interactions. In the case of the in vivo studies, they should address the in vivo regeneration capability of the stem cells or stem cells-based 3D substitutes. In addition, a particular interest will be given to studies exploring or discussing the possible role and fate of the stem cells in vivo, as well their advantage, disadvantage, or even negative ex vivo or in vivo results.

Potential topics include but are not limited to the following:

  • Biomaterials for 3D culture and differentiation of stem cells
  • Bioprinting technologies and stem cells
  • Stem cells-based scaffold-free tissue models
  • Impact of biomaterials structure and composition on stem cell behavior and differentiation
  • In vivo evaluation of stem cells behavior, fate, and host response
  • In vivo evaluation of tissue regeneration by using stem cells-based 3D substitutes
  • In vivo transplantation strategies for stem cells or stem cells-based 3D substitutes

Articles

  • Special Issue
  • - Volume 2018
  • - Article ID 7143930
  • - Editorial

Ex Vivo and In Vivo Stem Cells-Based Tissue Engineering Strategies for Their Use in Regenerative Medicine

Víctor Carriel | Stefano Geuna | Miguel Alaminos
  • Special Issue
  • - Volume 2018
  • - Article ID 6169546
  • - Research Article

Transplantation of Human Amniotic Membrane over the Liver Surface Reduces Hepatic Fibrosis in a Cholestatic Model in Young Rats

M. Garrido | C. Escobar | ... | S. Montedonico
  • Special Issue
  • - Volume 2017
  • - Article ID 9142493
  • - Research Article

High Sensitivity of Human Adipose Stem Cells to Differentiate into Myofibroblasts in the Presence of C. aspersa Egg Extract

Natalio García-Honduvilla | Alberto Cifuentes | ... | Melchor Alvarez-Mon
  • Special Issue
  • - Volume 2017
  • - Article ID 2905104
  • - Research Article

Therapeutic Benefit for Late, but Not Early, Passage Mesenchymal Stem Cells on Pain Behaviour in an Animal Model of Osteoarthritis

Victoria Chapman | Hareklea Markides | ... | Alicia J. El Haj
  • Special Issue
  • - Volume 2017
  • - Article ID 6319129
  • - Research Article

Influence of Different ECM-Like Hydrogels on Neurite Outgrowth Induced by Adipose Tissue-Derived Stem Cells

E. Oliveira | R. C. Assunção-Silva | ... | A. J. Salgado
  • Special Issue
  • - Volume 2017
  • - Article ID 6597815
  • - Review Article

Xeno-Free Strategies for Safe Human Mesenchymal Stem/Stromal Cell Expansion: Supplements and Coatings

M. Cimino | R. M. Gonçalves | ... | M. C. L. Martins
  • Special Issue
  • - Volume 2017
  • - Article ID 1764523
  • - Research Article

Tissue Engineering to Repair Diaphragmatic Defect in a Rat Model

G. P. Liao | Y. Choi | ... | Y. Li
  • Special Issue
  • - Volume 2017
  • - Article ID 4740709
  • - Review Article

The Use of Adipose-Derived Stem Cells in Selected Skin Diseases (Vitiligo, Alopecia, and Nonhealing Wounds)

Agnieszka Owczarczyk-Saczonek | Anna Wociór | ... | Joanna Wojtkiewicz
  • Special Issue
  • - Volume 2017
  • - Article ID 8309256
  • - Research Article

In Vivo Articular Cartilage Regeneration Using Human Dental Pulp Stem Cells Cultured in an Alginate Scaffold: A Preliminary Study

Manuel Mata | Lara Milian | ... | Carmen Carda
  • Special Issue
  • - Volume 2017
  • - Article ID 4206187
  • - Research Article

Ex Vivo Expansion of Human Limbal Epithelial Cells Using Human Placenta-Derived and Umbilical Cord-Derived Mesenchymal Stem Cells

Sang Min Nam | Yong-Sun Maeng | ... | Helen Lew
Stem Cells International
 Journal metrics
Acceptance rate44%
Submission to final decision76 days
Acceptance to publication35 days
CiteScore7.200
Impact Factor3.869
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