Stem Cells International

Vascular Diseases and Metabolic Disorders


Status
Published

Lead Editor

1Leuven University, Leuven, Belgium

2Stem Cell Institute, Leuven, Belgium

3Zhejiang University, Hangzhou, China


Vascular Diseases and Metabolic Disorders

Description

Maintenance of endothelium integrity is critical for prevention and treatment of vascular diseases. Unfortunately, endothelial cells undergo dysfunction and apoptosis when triggered by oxidative stress, inflammation, and some adverse metabolites. Stem and progenitor cells hold tremendous therapeutic potential for cell renewal. After decades of investigation, much knowledge has been gained regarding stem and progenitor cell differentiation into vascular cells. These include differentiation capacity, pathways modulating lineage specification, and genetic/phenotypic properties under both physiological and pathological conditions.

Nevertheless, given the complexity of disease pathogenesis, our understanding of how vascular cells act in diseases is still limited. And it becomes more complicated when combined with metabolic disorders. Therefore, therapeutic application of stem and progenitors-derived vascular cells in vascular diseases combined with metabolic disorders is still to be testified. For instance, reprogramming protocols used in the generation of induced pluripotent stem cells (iPSC) require further optimization to enhance production efficiency, improve safety, and acquire developmentally sufficient homogenous cell-derived products. Likewise, it is yet unknown how to accurately control stem and progenitor cell differentiation toward vascular lineages in vitro and in vivo. Thus, there remains a substantial gap between basic research and clinical practice in cell based therapies.

In this special issue, we invite original articles and reviews related to vascular biology and pathology. In vitro work as well as animal and clinical studies are all encouraged.

Potential topics include but are not limited to the following:

  • New findings of vascular cell biology and pathology in vascular diseases and metabolic disorders
  • Advanced strategies and technologies in stem cell reprogramming and differentiation toward vascular cells
  • Functional exploration and assessment of stem cell-derived vascular cells in the treatment of vascular diseases and metabolic disorders
  • Clinical findings and description of stem cells that might participate in vascular diseases and metabolic disorders
  • The discovery, isolation, characterization, and differentiation of novel adult stem cell populations that could generate vascular system

Articles

  • Special Issue
  • - Volume 2016
  • - Article ID 5810358
  • - Editorial

Vascular Diseases and Metabolic Disorders

Ying-Mei Feng | Catherine Verfaillie | Hong Yu
  • Special Issue
  • - Volume 2016
  • - Article ID 8737589
  • - Review Article

Growth Hormone-Releasing Hormone and Its Analogues: Significance for MSCs-Mediated Angiogenesis

Xiangyang Xia | Quanwei Tao | ... | Hong Yu
  • Special Issue
  • - Volume 2016
  • - Article ID 1803989
  • - Review Article

Endothelial Progenitor Cells in Diabetic Microvascular Complications: Friends or Foes?

Cai-Guo Yu | Ning Zhang | ... | Dong Zhao
  • Special Issue
  • - Volume 2016
  • - Article ID 7369491
  • - Research Article

The Engrailed-1 Gene Stimulates Brown Adipogenesis

Chuanhai Zhang | Yibing Weng | ... | Wanzhu Jin
  • Special Issue
  • - Volume 2016
  • - Article ID 8160318
  • - Research Article

Association between Toll-Like Receptor 4 and Occurrence of Type 2 Diabetes Mellitus Susceptible to Pulmonary Tuberculosis in Northeast China

Yuze Li | Dianzhong Li | ... | Kun Wu
  • Special Issue
  • - Volume 2016
  • - Article ID 7961816
  • - Review Article

Control of Cross Talk between Angiogenesis and Inflammation by Mesenchymal Stem Cells for the Treatment of Ocular Surface Diseases

Fei Li | Shao-zhen Zhao
  • Special Issue
  • - Volume 2016
  • - Article ID 6925357
  • - Clinical Study

Transcatheter Arterial Infusion of Autologous CD133+ Cells for Diabetic Peripheral Artery Disease

Xiaoping Zhang | Weishuai Lian | ... | Maoquan Li
  • Special Issue
  • - Volume 2016
  • - Article ID 6786184
  • - Research Article

Downregulation of the Yes-Associated Protein Is Associated with Extracellular Matrix Disorders in Ascending Aortic Aneurysms

Haiyang Li | Wenjian Jiang | ... | Hongjia Zhang
  • Special Issue
  • - Volume 2016
  • - Article ID 6175948
  • - Research Article

Residual Dyslipidemia Leads to Unfavorable Outcomes in Patients with Acute Coronary Syndrome after Percutaneous Coronary Intervention

Bin Que | Chunmei Wang | ... | Shaoping Nie
  • Special Issue
  • - Volume 2016
  • - Article ID 4035307
  • - Research Article

Endovascular Management of Aorta-Iliac Stenosis and Occlusive Disease by Kissing-Stent Technique

Meng Liu | Fuxian Zhang
Stem Cells International
 Journal metrics
Acceptance rate44%
Submission to final decision76 days
Acceptance to publication35 days
CiteScore7.200
Impact Factor3.869
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