Stem Cells International

Stem Cell-Released Microvesicles and Exosomes as Novel Biomarkers and Treatments of Diseases


Status
Published

Lead Editor

1Wright State University, Dayton, USA

2Rush University, Chicago, USA

3Georgia Regents University, Augusta, USA


Stem Cell-Released Microvesicles and Exosomes as Novel Biomarkers and Treatments of Diseases

Description

Extracellular microvesicles (MVs) and exosomes (EXs) are recognized as potential biomarkers for a wide spectrum of diseases including vascular diseases, neurological diseases, and cancers. Because of their ability in mediating cell-cell communication, MVs and EXs are functional. Although their functions are largely unknown, MVs and EXs are important therapeutic targets/tools of diseases. It has been suggested that circulating miRNAs are mainly encapsulated in MVs/EXs, which transport miRNAs from parental cells to neighboring and distant cells. Although significant advances have been made in the field of stem cell research during the past decades, there is less information regarding the physiological and pathological roles of MVs and EXs released from stem cells. Meanwhile, there is an urgent need for identifying sensitive and specific biomarkers of different diseases and developing new therapies for these unmet medical needs.

In the current special issue, reviews and original articles about novel studies of stem cell-released MVs and EXs as biomarkers and treatments of cardiovascular and neurological diseases and tumors are welcomed.

Potential topics include, but are not limited to:

  • Novel methodologies for isolation, detection, and purification of MVs and EXs released from stem cells, such as endothelial progenitors, neuron progenitors, tumor stem cells, and novel animal models and experimental procedures for facilitating the research of MVs/EXs
  • Characterizing the cargos carried by MVs and EXs released from stem cells, including microRNAs, lncRNAs, proteins, and mRNAs
  • Novel biomarkers of MVs and EXs released from stem cells for cardiovascular and neurological diseases and tumors which improve the sensitivity and specificity over current biomarkers
  • Novel treatments/targets of MVs and EXs for cardiovascular and neurological diseases and tumors
  • Preclinical and clinical studies that help in understanding the pathology underlying cardiovascular and neurological diseases and tumors

Articles

  • Special Issue
  • - Volume 2016
  • - Article ID 2417268
  • - Editorial

Stem Cell-Released Microvesicles and Exosomes as Novel Biomarkers and Treatments of Diseases

Yanfang Chen | Yaoliang Tang | ... | Chunxiang Zhang
  • Special Issue
  • - Volume 2016
  • - Article ID 8357567
  • - Research Article

Hepatic Stellate Cell-Derived Microvesicles Prevent Hepatocytes from Injury Induced by APAP/H2O2

Renwei Huang | Qunwen Pan | ... | Huilai Miao
  • Special Issue
  • - Volume 2016
  • - Article ID 4328362
  • - Review Article

Inhibition of Myocardial Ischemia/Reperfusion Injury by Exosomes Secreted from Mesenchymal Stem Cells

Heng Zhang | Meng Xiang | ... | Sifeng Chen
  • Special Issue
  • - Volume 2016
  • - Article ID 5736059
  • - Review Article

Potential Therapies by Stem Cell-Derived Exosomes in CNS Diseases: Focusing on the Neurogenic Niche

Alejandro Luarte | Luis Federico Bátiz | ... | Carlos Lafourcade
  • Special Issue
  • - Volume 2016
  • - Article ID 4796578
  • - Research Article

Multilayer Membranes of Glycosaminoglycans and Collagen I Biomaterials Modulate the Function and Microvesicle Release of Endothelial Progenitor Cells

Bingyan Dai | Qunwen Pan | ... | Xiaotang Ma
  • Special Issue
  • - Volume 2016
  • - Article ID 9313425
  • - Research Article

Leukemia Stem Cell-Released Microvesicles Promote the Survival and Migration of Myeloid Leukemia Cells and These Effects Can Be Inhibited by MicroRNA34a Overexpression

Yue Wang | Qian Cheng | ... | Min Dong
  • Special Issue
  • - Volume 2016
  • - Article ID 3409169
  • - Review Article

Harnessing the Angiogenic Potential of Stem Cell-Derived Exosomes for Vascular Regeneration

F. Alcayaga-Miranda | M. Varas-Godoy | M. Khoury
  • Special Issue
  • - Volume 2016
  • - Article ID 2639728
  • - Research Article

The Novel Methods for Analysis of Exosomes Released from Endothelial Cells and Endothelial Progenitor Cells

Jinju Wang | Runmin Guo | ... | Ji C. Bihl
  • Special Issue
  • - Volume 2016
  • - Article ID 6146047
  • - Research Article

Synovial Sarcoma Microvesicles Harbor the SYT-SSX Fusion Gene Transcript: Comparison of Different Methods of Detection and Implications in Biomarker Research

A. Fricke | P. V. Ullrich | ... | S. U. Eisenhardt
  • Special Issue
  • - Volume 2016
  • - Article ID 7315830
  • - Research Article

The Comparison of Adipose Stem Cell and Placental Stem Cell in Secretion Characteristics and in Facial Antiaging

Yan Xu | Shilei Guo | ... | Chuansen Zhang
Stem Cells International
 Journal metrics
Acceptance rate44%
Submission to final decision76 days
Acceptance to publication35 days
CiteScore7.200
Impact Factor3.869
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