Stem Cells International

Mesenchymal Stem Cells in the Tumour Microenvironment

Publishing date
01 Oct 2021
Submission deadline
21 May 2021

Lead Editor

1Xuzhou Central Hospital, Xuzhou Clinical School of Xuzhou Medical College, Xuzhou, China

2Jiangsu University, Zhenjiang, China

3The First Affiliated Hospital of Anhui Medical University, Hefei, China

4Mayo Clinic College of Medicine, Rochester, USA

This issue is now closed for submissions.

Mesenchymal Stem Cells in the Tumour Microenvironment

This issue is now closed for submissions.


Emerging evidence indicates that mesenchymal stem cells (MSCs) play an important role in tumour progression. MSCs from different sources may have distinct effects on tumours. Tumour-associated MSCs (TA-MSCs) promote tumour progression, including growth, angiogenesis, invasive ability, and metastasis of tumour cells, by secreting some growth factors, exosomes, or by other mechanisms. Human umbilical cord-derived MSCs (hUCMSCs) do not promote proliferation and also inhibit the migration of tumour cells. In addition, they inhibit tube formation in human umbilical vein endothelial cells (HUVECs).

MSCs are also engaged in the immunomodulatory function of B cells, dendritic cells, macrophages, and myeloid-derived suppressor cells (MDSCs). Therefore, it is easily understandable that MSCs interact with immune cells and other cells in the tumour microenvironment (TME). It is of profound significance to explore the role of MSCs in tumour progression and therapy.

In this Special Issue, we invite investigators to contribute original research articles as well as review articles that provide novel insights into the role of MSCs in tumours and tumour immunity, which could meaningfully contribute to clinical tumour diagnosis and treatment.

Potential topics include but are not limited to the following:

  • MSCs from various sources, including bone marrow-derived mesenchymal stem cells (BMMSC), TA-MSCs, hUCMSCs, etc.
  • How MSCs regulate tumour progression
  • Bidirectional regulation between MSCs and tumour cells or immune cells
  • The biological effects of MSCs on tumour cells or immune cells
  • Tumour immunotherapy of MSCs
  • The effects of MSCs on tumour drug resistance
  • MicroRNAs, exosomes, or other molecules regulating the MSCs-mediated tumour or tumour immunity progression
  • MSCs and immune check-points
  • The association between MSCs and markers or prognosis
Stem Cells International
 Journal metrics
See full report
Acceptance rate15%
Submission to final decision153 days
Acceptance to publication27 days
Journal Citation Indicator0.800
Impact Factor4.3
 Submit Check your manuscript for errors before submitting

Article of the Year Award: Impactful research contributions of 2022, as selected by our Chief Editors. Discover the winning articles.