Conditions such as trauma-induced bone or cartilage defects and tumor or congenital defects are common in the oral and maxillofacial regions. Bone grafts are the current gold standard strategy for repairing irreversible skeletal damage or defects.

However, bone grafts can present problems such as the availability of bone graft material and donor-site morbidity. It is also still difficult to restore salivary glands that have been severely damaged by radiation therapy. In order to counteract, neurodegeneration is induced by trauma or surgery. In addition, due to the limited self-healing ability of teeth, dental caries is treated by fillings (e.g., composite resin) or crowns, and missing teeth are replaced through dental bridges, removable dentures, or dental implants. Therefore, it is necessary to establish new treatment strategies for these conditions. One of the most recent effective strategies is to introduce stem cell-based tissue engineering technology in the oral and maxillofacial regions. Accordingly, numerous studies have been conducted and many promising results have been reported. However, achieving effective stem cell-based tissue engineering therapy in this region of the body remains a challenge.

The aim of this Special Issue is to attract original research articles and review articles addressing current advances in stem cell and biomaterial research related to the development of the regeneration of oral and maxillofacial bone, cartilage, or neurons. Submissions focussing on regeneration development in salivary glands or teeth are also welcome.

Potential topics include but are not limited to the following:

• Use of stem cells in oral and maxillofacial bone, cartilage, or neuron tissue engineering
• Use of stem cells in salivary gland or tooth tissue engineering
• Characterization and culture of stem cells derived from the oral and maxillofacial region (e.g., dental pulp stem cells, periodontal ligament stem cells)
• Delivery technologies for stem cell-based tissue regeneration in the oral and maxillofacial regions