Stem Cells International

Stem Cells in Cartilage Regeneration


Status
Published

Lead Editor

1University of Pittsburgh Medical School, Pittsburgh, USA

2Third Military Medical University, Chongqing, China

3University of Pittsburgh, Pittsburgh, USA

4Yeshiva University, New York, USA

5General Hospital of Shenyang Military Command, Shenyang, China


Stem Cells in Cartilage Regeneration

Description

Cartilage remains one of the most difficult tissues to regenerate. Several approaches including stem cell therapy have been developed in the past decade to repair damaged articular cartilage, intervertebral disc, and meniscus. Current approaches using culture-expanded chondrocytes, bone marrow mesenchymal stem cells, or pluripotent stem cells with chondroinductive growth factors are able to generate cartilaginous tissue within articular cartilage defects but do not form hyaline cartilage-based articular surfaces. Meanwhile, the mechanical and functional characteristics of repaired cartilage are often unsatisfactory compared with the native cartilage.

At the cellular level, the challenges faced in cartilage regeneration include the regulation of stem cells during chondrogenic differentiation, chondrocyte dedifferentiation, chondrocyte hypertrophy, and maintenance of the cartilage phenotype.

We invite investigators to contribute original research articles as well as review articles that will stimulate continuing efforts on stem cell research in cartilage tissue regeneration and increase the overall understanding of fundamental stem cell biology (regulatory mechanisms of self-renewal and differentiation).

Potential topics include but are not limited to the following:

  • Characterization and differences among cartilage stem cells and various cartilage cells
  • Chondrogenic differentiation and chondrocyte dedifferentiation of various stem cells including bone marrow mesenchymal stem cells (MSCs), embryonic stem cells (ESCs), adipose-derived stem cells (ASCs), and tendon stem cells (TSCs)
  • Chondrocyte hypertrophy
  • Cartilage injury (articular cartilage, intervertebral disc, meniscus, etc.) mechanism and treatment
  • Regenerative medicine (tissue engineering, biomaterials, drug delivery, etc.) on cartilage
  • Mechanical factors on stem cell differentiation in cartilage maintenance and repair
  • Clinical applications of stem cell therapy in cartilage repair

Articles

  • Special Issue
  • - Volume 2017
  • - Article ID 7034726
  • - Editorial

Stem Cells in Cartilage Regeneration

Jianying Zhang | Shiwu Dong | ... | Kai Tao
  • Special Issue
  • - Volume 2017
  • - Article ID 4130607
  • - Review Article

Advances and Prospects in Stem Cells for Cartilage Regeneration

Mingjie Wang | Zhiguo Yuan | ... | Quanyi Guo
  • Special Issue
  • - Volume 2017
  • - Article ID 1709582
  • - Research Article

Adipose-Derived Stem Cells Cocultured with Chondrocytes Promote the Proliferation of Chondrocytes

Jie Shi | Jiulong Liang | ... | Kai Tao
  • Special Issue
  • - Volume 2017
  • - Article ID 9312329
  • - Research Article

Isolation and Characterization of Synovial Mesenchymal Stem Cell Derived from Hip Joints: A Comparative Analysis with a Matched Control Knee Group

Akihisa Hatakeyama | Soshi Uchida | ... | Akinori Sakai
  • Special Issue
  • - Volume 2016
  • - Article ID 2470351
  • - Review Article

The Signaling Pathways Involved in Chondrocyte Differentiation and Hypertrophic Differentiation

Jianmei Li | Shiwu Dong
  • Special Issue
  • - Volume 2016
  • - Article ID 5093725
  • - Research Article

Isolation, Characterization, and Multipotent Differentiation of Mesenchymal Stem Cells Derived from Meniscal Debris

Weili Fu | Xing Xie | ... | Jian Li
  • Special Issue
  • - Volume 2016
  • - Article ID 8235172
  • - Research Article

Regulatory Mechanisms of the Ihh/PTHrP Signaling Pathway in Fibrochondrocytes in Entheses of Pig Achilles Tendon

Xuesong Han | Yanfeng Zhuang | ... | Wanming Wang
  • Special Issue
  • - Volume 2016
  • - Article ID 6969726
  • - Research Article

Chondrogenic Potency Analyses of Donor-Matched Chondrocytes and Mesenchymal Stem Cells Derived from Bone Marrow, Infrapatellar Fat Pad, and Subcutaneous Fat

John Garcia | Claire Mennan | ... | Karina T. Wright
  • Special Issue
  • - Volume 2016
  • - Article ID 9042019
  • - Research Article

A Controlled Release Codelivery System of MSCs Encapsulated in Dextran/Gelatin Hydrogel with TGF-β3-Loaded Nanoparticles for Nucleus Pulposus Regeneration

Yibo Gan | Sukai Li | ... | Qiang Zhou
  • Special Issue
  • - Volume 2016
  • - Article ID 8283257
  • - Research Article

Differential Characterization of Two Kinds of Stem Cells Isolated from Rabbit Nucleus Pulposus and Annulus Fibrosus

Chenglin Sang | Xuecheng Cao | ... | Yongxian Zhang
Stem Cells International
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Acceptance rate44%
Submission to final decision76 days
Acceptance to publication35 days
CiteScore7.200
Impact Factor3.869
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