Stem Cells International

Mesenchymal Stem Cells as Promoters, Enhancers, and Playmakers of the Translational Regenerative Medicine


Publishing date
10 Feb 2017
Status
Published
Submission deadline
23 Sep 2016

Lead Editor

1University of Bari “Aldo Moro”, Bari, Italy

2Tecnologica Research Institute, Crotone, Italy

3University of Cambridge, Cambridge, UK

4Université Pierre et Marie Curie, Paris, France


Mesenchymal Stem Cells as Promoters, Enhancers, and Playmakers of the Translational Regenerative Medicine

Description

Mesenchymal stem cells (MSCs) are currently being tested in preclinical and clinical trials for their ability to foster wound healing and tissue regeneration.

They are well known to show a therapeutic potential largely depending on their ability to secrete proregenerative cytokines, making these cells an attractive option for improving the treatment of chronic wounds. The wound microenvironment is a miscellaneous key-factor in the local management of the healing process: players such as the extracellular matrix or the resident and recruited cells with paracrine activity are able to determine the way and the appropriateness of the regenerative processes.

Despite the multiple barriers to their clinical use, MSCs have shown sufficient promise to garner a primary place in the field of regenerative medicine. MSCs therapies have significant implications for human health: clinical studies are greatly needed to confirm or stimulate the basic and translational researches aimed to reach cutting-edge results.

In this special issue, we invite worldwide researchers as well as the clinicians confident in the regenerative medicine to submit their most interesting overviews, reviews, and original papers describing the good, the bad, and the ugly of MSCs in wound healing and tissue regeneration. Innovative aspects of MSCs biology, within the context of isolation, derivation, reprogramming, self-renewal, quality control, differentiation, transplantation, new sources of MSCs, and other similar studies are warmly welcome topics.

Potential topics include, but are not limited to:

  • Mesenchymal stem cells in translational research and therapeutic strategies towards tissue regeneration and wound healing
  • Growth factors effects on mesenchymal stem cells
  • Mesenchymal stem cells delivery/routes
  • Inflammation/immunomodulation and mesenchymal stem cells activity
  • Extracellular matrix and bioactive molecules
  • New methodological paradigms that challenge current thinking in clinical mesenchymal stem cells research, including feasibility and “proof-of-concept” studies
  • Development of clinical-grade mesenchymal stem cells under good manufacturing practice protocols/conditions as an essential step towards clinical application or other relevant topics

Articles

  • Special Issue
  • - Volume 2017
  • - Article ID 3292810
  • - Editorial

Mesenchymal Stem Cells as Promoters, Enhancers, and Playmakers of the Translational Regenerative Medicine

Andrea Ballini | Salvatore Scacco | ... | Marco Tatullo
  • Special Issue
  • - Volume 2017
  • - Article ID 6202783
  • - Research Article

Cytokine, Chemokine, and Growth Factor Profile Characterization of Undifferentiated and Osteoinduced Human Adipose-Derived Stem Cells

F. Mussano | T. Genova | ... | S. Carossa
  • Special Issue
  • - Volume 2017
  • - Article ID 9082869
  • - Research Article

Bone Regeneration Induced by Bone Porcine Block with Bone Marrow Stromal Stem Cells in a Minipig Model of Mandibular “Critical Size” Defect

Antonio Scarano | Vito Crincoli | ... | Felice Roberto Grassi
  • Special Issue
  • - Volume 2017
  • - Article ID 5270527
  • - Research Article

Paracrine Effects of Bone Marrow Mononuclear Cells in Survival and Cytokine Expression after 90% Partial Hepatectomy

Carlos Oscar Kieling | Carolina Uribe-Cruz | ... | Ursula Matte
  • Special Issue
  • - Volume 2017
  • - Article ID 9453108
  • - Review Article

The Roles of Insulin-Like Growth Factors in Mesenchymal Stem Cell Niche

Amer Youssef | Doaa Aboalola | Victor K. M. Han
  • Special Issue
  • - Volume 2017
  • - Article ID 3978595
  • - Review Article

Therapeutic Potential of Olfactory Ensheathing Cells and Mesenchymal Stem Cells in Spinal Cord Injuries

Zadroga Anna | Jezierska-Woźniak Katarzyna | ... | Maksymowicz Wojciech
  • Special Issue
  • - Volume 2017
  • - Article ID 5173732
  • - Review Article

Mesenchymal Stem and Progenitor Cells in Regeneration: Tissue Specificity and Regenerative Potential

Rokhsareh Rohban | Thomas Rudolf Pieber
  • Special Issue
  • - Volume 2017
  • - Article ID 3537094
  • - Review Article

Mesenchymal Stem Cells for the Treatment of Spinal Arthrodesis: From Preclinical Research to Clinical Scenario

F. Salamanna | M. Sartori | ... | M. Fini
  • Special Issue
  • - Volume 2017
  • - Article ID 4985323
  • - Research Article

Overexpression of Heme Oxygenase-1 in Mesenchymal Stem Cells Augments Their Protection on Retinal Cells In Vitro and Attenuates Retinal Ischemia/Reperfusion Injury In Vivo against Oxidative Stress

Li Li | GaiPing Du | ... | Hua Jiang
  • Special Issue
  • - Volume 2017
  • - Article ID 7316354
  • - Research Article

Kindlin-2 Modulates the Survival, Differentiation, and Migration of Induced Pluripotent Cell-Derived Mesenchymal Stromal Cells

Mohsen Moslem | Reto Eggenschwiler | ... | Reinhard Henschler
Stem Cells International
 Journal metrics
Acceptance rate45%
Submission to final decision77 days
Acceptance to publication40 days
CiteScore3.800
Impact Factor3.902
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