Stem Cells International

Ex Vivo Generated Red Cells as Transfusion Products


Publishing date
01 Aug 2011
Status
Published
Submission deadline
01 Feb 2011

1Tisch Cancer Institute, Mount Sinai School of Medicine, New York, NY 10029, USA

2Centro Nazionale Sangue, 00162 Roma, Italy

3Memorial Sloan-Kettering Institute for Cancer Center, New York, NY 10065, USA

4New York Blood Center, New York, NY 10065, USA


Ex Vivo Generated Red Cells as Transfusion Products

Description

The global need for a safe and adequate blood supply has been an international priority for over 35 years. However, national disasters, emerging infections, political unrest, and economic problems have prevented attainment of these goals. Strategies to improve transfusion therapy have included the development of alternative blood transfusion products. Historically, these products have included soluble oxygen carriers such as recombinant/stabilized hemoglobin, synthetic oxygen carriers, and enzymatically treated red cells. Recently, the possibility to obtain large numbers of “erythroid cells” ex vivo from sources usually discarded, such as cord blood and leukocytes from adult blood, has increased the possibility that erythroid cells expanded ex vivo may represent a valid alternative transfusion product. Since red cells do not have a nucleus and pose lower risk of oncogenicity, it has been proposed that erythroid cells derived ex vivo from human embryonic stem cells and induced pluripotency stem cells will represent the first personalized medicinal product.We are interested in top-notch articles that define the state of the art on development of ex vivo generated erythroid transfusion products. Both positive and cautionary papers are welcome. Manuscripts should address topics that include, but are not limited to:

  • Need for alternative products for transfusion
  • Culture conditions for ex vivo expansion of erythroid cells for transfusion
  • Scaled-up production of erythroid cells for transfusion
  • Stem cell sources for ex vivo erythroid cell expansion including human embryonic stem cells and induced pluripotency stem cells
  • Epigenetic modulation of erythroid potency
  • Conditions for ex vivo enucleation of erythroid cells
  • Immunological challenges and other safety issues posed by ex vivo generated erythroid cells
  • Applications of ex vivo expanded erythroid cells for diagnostics and systemic gene and protein delivery
  • Any topic that the authors believe is relevant to this subject including additional cell therapy products for transfusion (platelets, dendritic cells, etc.)

Articles published in this special issue will not be subject to the journal's Article Processing Charges.

Before submission authors should carefully read over the journal's Author Guidelines, which are located at http://www.hindawi.com/journals/sci/guidelines/. Prospective authors should submit an electronic copy of their complete manuscript through the journal Manuscript Tracking System at http://mts.hindawi.com/ according to the following timetable:


Articles

  • Special Issue
  • - Volume 2012
  • - Article ID 615412
  • - Editorial

Ex Vivo Generated Red Cells as Transfusion Products

Anna Rita Migliaccio | Giuliano Grazzini | Christopher D. Hillyer
  • Special Issue
  • - Volume 2012
  • - Article ID 639561
  • - Review Article

Alternative Blood Products and Clinical Needs in Transfusion Medicine

Carolyn Whitsett | Stefania Vaglio | Giuliano Grazzini
  • Special Issue
  • - Volume 2011
  • - Article ID 791604
  • - Review Article

Generation and Characterization of Erythroid Cells from Human Embryonic Stem Cells and Induced Pluripotent Stem Cells: An Overview

Kai-Hsin Chang | Halvard Bonig | Thalia Papayannopoulou
  • Special Issue
  • - Volume 2011
  • - Article ID 139851
  • - Review Article

Erythroblast Enucleation

Ganesan Keerthivasan | Amittha Wickrema | John D. Crispino
  • Special Issue
  • - Volume 2011
  • - Article ID 602483
  • - Research Article

Phenotypic Definition of the Progenitor Cells with Erythroid Differentiation Potential Present in Human Adult Blood

Valentina Tirelli | Barbara Ghinassi | ... | Giovanni Migliaccio
  • Special Issue
  • - Volume 2011
  • - Article ID 405429
  • - Research Article

Human Fetal Liver: An In Vitro Model of Erythropoiesis

Guillaume Pourcher | Christelle Mazurier | ... | Hélène Lapillonne
  • Special Issue
  • - Volume 2011
  • - Article ID 434392
  • - Review Article

Optimization Manufacture of Virus- and Tumor-Specific T Cells

Natalia Lapteva | Juan F. Vera
  • Special Issue
  • - Volume 2011
  • - Article ID 673752
  • - Research Article

Recovery and Biodistribution of Ex Vivo Expanded Human Erythroblasts Injected into NOD/SCID/IL2R 𝜸 n u l l mice

Barbara Ghinassi | Leda Ferro | ... | Anna Rita Migliaccio
  • Special Issue
  • - Volume 2011
  • - Article ID 195780
  • - Review Article

Plasticity of Cells and Ex Vivo Production of Red Blood Cells

Takashi Hiroyama | Kenichi Miharada | ... | Yukio Nakamura
Stem Cells International
 Journal metrics
Acceptance rate45%
Submission to final decision76 days
Acceptance to publication35 days
CiteScore3.800
Impact Factor3.902
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