Stem Cells International

iPSCs: From Bench to Clinical Bed


Publishing date
11 Dec 2015
Status
Published
Submission deadline
24 Jul 2015

Lead Editor

1Emory University, Atlanta, USA

2Institute of Biology and Experimental Medicine (IBYME-CONICET), Buenos Aires, Argentina

3Zhejiang University, Hangzhou, China


iPSCs: From Bench to Clinical Bed

Description

Induced pluripotent stem cells (iPSCs) have been acknowledged as a milestone in the field of stem cell biology and regenerative medicine, providing an excellent tool to tackle fundamental biological questions regarding (de)differentiation and epigenetics and the valuable cell sources for tissue regeneration, human disease modeling, and drug discovery. Further, iPSC generation with patient-specific somatic cells holds great promise for autologous cell replacement therapy. Since the discovery of the iPSCs, efforts have been mainly made to develop protocols with high efficiency and safety to generate clinically relevant cells by employing a variety of (epi) genetic and biochemical approaches. Indeed, some protocols have become practical to significantly enhance the efficiency of iPSCs induction. Also, we have a better insight into the molecular mechanisms controlling iPSC generation at the level of genetics and epigenetics. Meanwhile, approaches regarding the application of iPSCs in animal models for human diseases have been extensively studied.

We invite experts in the field of stem cell, development, and genetics that are mainly studying iPSC-related research from iPSC generation/differentiation protocols and fundamental biological questions to regenerative medicine and human disease modeling.

Potential topics include, but are not limited to:

  • Generation of iPSCs: methods that significantly enhance efficiency and safety for potential clinical use
  • Directed differentiation of iPSCs
  • Direct cell reprogramming
  • Applications of iPSCs in regenerative medicine
  • Applications of iPSCs in animal models for human disease
  • Applications of iPSCs in drug screening and drug discovery
  • Applications of iPSCs in fundamental biological research particularly the molecular and epigenetic mechanisms of reprogramming, proliferation, and differentiation
  • Genomic editing approaches for iPSCs

Articles

  • Special Issue
  • - Volume 2016
  • - Article ID 8367587
  • - Editorial

iPSCs: From Bench to Clinical Bed

Yujing Li | Changwon Park | ... | Xuekun Li
  • Special Issue
  • - Volume 2016
  • - Article ID 7828049
  • - Review Article

Modeling Alzheimer’s Disease with Induced Pluripotent Stem Cells: Current Challenges and Future Concerns

Weiwei Zhang | Bin Jiao | ... | Lu Shen
  • Special Issue
  • - Volume 2016
  • - Article ID 6853081
  • - Research Article

Extracellular Matrix-Dependent Generation of Integration- and Xeno-Free iPS Cells Using a Modified mRNA Transfection Method

Kang-In Lee | Seo-Young Lee | Dong-Youn Hwang
  • Special Issue
  • - Volume 2016
  • - Article ID 2681925
  • - Review Article

LncRNAs in Stem Cells

Shanshan Hu | Ge Shan
  • Special Issue
  • - Volume 2016
  • - Article ID 5934782
  • - Review Article

iPSCs: A Minireview from Bench to Bed, including Organoids and the CRISPR System

Andrés Javier Orqueda | Carla Alejandra Giménez | Federico Pereyra-Bonnet
  • Special Issue
  • - Volume 2016
  • - Article ID 6484713
  • - Review Article

The Application of Human iPSCs in Neurological Diseases: From Bench to Bedside

Nina Xie | Beisha Tang
  • Special Issue
  • - Volume 2016
  • - Article ID 4126214
  • - Review Article

The Progress of Induced Pluripotent Stem Cells as Models of Parkinson’s Disease

Ji-feng Kang | Bei-sha Tang | Ji-feng Guo
  • Special Issue
  • - Volume 2016
  • - Article ID 8415010
  • - Review Article

Induced Pluripotent Stem Cells: Generation Strategy and Epigenetic Mystery behind Reprogramming

Pengfei Ji | Sasicha Manupipatpong | ... | Yujing Li
  • Special Issue
  • - Volume 2016
  • - Article ID 4626048
  • - Research Article

Human Umbilical Cord Blood-Derived Serum for Culturing the Supportive Feeder Cells of Human Pluripotent Stem Cell Lines

Ruttachuk Rungsiwiwut | Praewphan Ingrungruanglert | ... | Kamthorn Pruksananonda
Stem Cells International
 Journal metrics
Acceptance rate45%
Submission to final decision76 days
Acceptance to publication40 days
CiteScore3.800
Impact Factor3.902
 Submit