Stem Cells International

Stem Cells in Cartilage Diseases and Repair 2018


Status
Published

Lead Editor

1University of Pittsburgh Medical School, Pittsburgh, USA

2Third Military Medical University, Chongqing, China

3University of Pittsburgh, Pittsburgh, USA

4Yeshiva University, New York, USA

5General Hospital of Shenyang Military Command, Shenyang, China


Stem Cells in Cartilage Diseases and Repair 2018

Description

Cartilage is an important connective tissue found in many areas of the body including the joints between bones (the hips, elbows, knees, and ankles), the rib cage, the ear, the nose, the bronchial tubes, meniscus, and the intervertebral discs. Cartilage disorders affect millions of people worldwide. It has been reported that about 80% of population at some time during their lifetime have low back pain caused by intervertebral disc degeneration. The cost of chronic low back pain exceeds the combined costs of stroke, respiratory infection, diabetes, coronary artery disease, and rheumatoid disease. There is no suitable and effective treatment for these cartilage diseases due to the lack of understanding cellular and molecular mechanisms that underlie these cartilage diseases. In particular, the stem cell effects in these cartilage diseases remain largely unknown. In fact, the restoration of normal structure and function of injured cartilages represents one of the most challenging areas in orthopedic medicine.

Cartilage remains one of the most difficult tissues to regenerate. Several approaches including tissue engineering and stem cell therapy have been developed in the past decade to repair damaged articular cartilage, intervertebral disc, and meniscus. However, the progress has been hindered by a lack of understanding the characterization of cartilage cells and pathogenic mechanisms of cartilage diseases.

At the cellular level, the challenges faced in cartilage diseases and regeneration include understanding the molecular biology of chondrocytes in cartilage injuries and repair, the regulation of stem cells during chondrogenic differentiation, chondrocyte dedifferentiation, chondrocyte hypertrophy, maintenance of the cartilage phenotype, and cartilage damages.

We invite investigators to contribute original research articles as well as review articles that will stimulate continuing efforts on stem cell research in cartilage diseases and repair/regeneration and increase the overall understanding of fundamental stem cell biology (regulatory mechanisms of self-renewal and differentiation).

Potential topics include but are not limited to the following:

  • Characterization and differences among cartilage stem cells and various cartilage cells
  • Chondrogenic differentiation and chondrocyte dedifferentiation of various stem cells including bone marrow mesenchymal stem cells (MSCs), embryonic stem cells (ESCs), adipose-derived stem cells (ASCs), and tendon stem cells (TSCs)
  • Chondrocyte hypertrophy
  • Cartilage injury (articular cartilage, intervertebral disc, meniscus, osteoarthritis, etc.) mechanism and treatment
  • Regenerative medicine (tissue engineering, biomaterials, drug delivery, etc.) on cartilage
  • Mechanical factors on stem cell differentiation in cartilage maintenance and repair
  • Clinical applications of stem cell therapy in cartilage repair

Articles

  • Special Issue
  • - Volume 2018
  • - Article ID 3672890
  • - Editorial

Stem Cells in Cartilage Diseases and Repair 2018

Jianying Zhang | Shiwu Dong | ... | Peng Chang
  • Special Issue
  • - Volume 2018
  • - Article ID 2791632
  • - Research Article

Intra-Articular Injection of Alginate-Microencapsulated Adipose Tissue-Derived Mesenchymal Stem Cells for the Treatment of Osteoarthritis in Rabbits

Seongjae Choi | Jun-Hyung Kim | ... | Byung-Jae Kang
  • Special Issue
  • - Volume 2018
  • - Article ID 4142031
  • - Research Article

Comparison of Regenerative Tissue Quality following Matrix-Associated Cell Implantation Using Amplified Chondrocytes Compared to Synovium-Derived Stem Cells in a Rabbit Model for Cartilage Lesions

Hagen Schmal | Justyna M. Kowal | ... | Eva J. Kubosch
  • Special Issue
  • - Volume 2018
  • - Article ID 4686259
  • - Research Article

Human Urine-Derived Stem Cells: Potential for Cell-Based Therapy of Cartilage Defects

Long Chen | Lang Li | ... | Zhou Xiang
  • Special Issue
  • - Volume 2018
  • - Article ID 7061898
  • - Research Article

Low Magnitude of Compression Enhances Biosynthesis of Mesenchymal Stem Cells towards Nucleus Pulposus Cells via the TRPV4-Dependent Pathway

Yibo Gan | Bing Tu | ... | Qiang Zhou
  • Special Issue
  • - Volume 2018
  • - Article ID 8947548
  • - Review Article

Adipose-Derived Mesenchymal Stem Cells in the Use of Cartilage Tissue Engineering: The Need for a Rapid Isolation Procedure

Sam L. Francis | Serena Duchi | ... | Peter F. M. Choong
  • Special Issue
  • - Volume 2018
  • - Article ID 5421019
  • - Review Article

Combating Osteoarthritis through Stem Cell Therapies by Rejuvenating Cartilage: A Review

Navneet Kumar Dubey | Viraj Krishna Mishra | ... | Win-Ping Deng
  • Special Issue
  • - Volume 2018
  • - Article ID 3237253
  • - Research Article

The Hypoxia-Mimetic Agent Cobalt Chloride Differently Affects Human Mesenchymal Stem Cells in Their Chondrogenic Potential

Gabriella Teti | Stefano Focaroli | ... | Mirella Falconi
  • Special Issue
  • - Volume 2018
  • - Article ID 3217895
  • - Research Article

Link Protein N-Terminal Peptide as a Potential Stimulating Factor for Stem Cell-Based Cartilage Regeneration

Ruijun He | Baichuan Wang | ... | Zengwu Shao
Stem Cells International
 Journal metrics
Acceptance rate44%
Submission to final decision76 days
Acceptance to publication35 days
CiteScore7.200
Impact Factor3.869
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