Stem Cells International

Promoting Tissue Repair by Micrograft Stem Cells Delivery


Publishing date
01 Nov 2019
Status
Published
Submission deadline
12 Jul 2019

Lead Editor

1University of Turin, Turin, Italy

2University of Sapienza, Rome, Italy

3UCL Eastman Dental Institute, London, UK


Promoting Tissue Repair by Micrograft Stem Cells Delivery

Description

Tissue repair/regeneration represents a big challenge for the scientific community which is always looking for new strategies able to promote these processes, especially for those tissues where the regenerative potential is very low. Furthermore, these strategies are directly related to improvements in the quality of life and clinical outcomes of patients requiring this type of intervention.

For regenerative medicine strategies to be successful, the material used (mostly combinations of scaffolds, growth factors, and stem cells) must be able to replace the damaged tissue and function as the original tissue did, or be able to stimulate regeneration of the original tissue. In this respect, tissue engineering is assuming a growing interest in the scientific community in order to promote tissue regeneration through the combined use of biomaterials and biologic mediators.

Tissue grafting is a widely used approach to repair a damaged area, and its success depends on the attachment or engraftment rate into the recipient site. This in turn can be regulated by three principal aspects: good vascularization of the recipient area, maximum adherence between the graft and the recipient site, and optimal immobilization of the graft to restore revascularization. This approach offers promising results and provides a rapid although temporary solution, but it can be extremely expensive, especially when the defect to be repaired is large and the availability of donor sites is limited. In contrast, micrografting techniques overcome the drawbacks of classical grafting, allowing for the coverage of a defect by utilizing a minimal amount of donor skin. However, while micrografting is an appealing strategy for wound coverage, additional studies are still needed to identify its true potential and pitfalls.

In this context, it becomes important to develop protocols or procedures able to maximize tissue repair/regeneration while preserving the cell viability and content of stem cells of grafts to optimize their rate of engraftment. Additionally, these strategies should have significant immunomodulatory effects to reduce the inflammatory environment typical of injured sites.

In this special issue, researchers are encouraged to submit original clinical research articles, clinical advances, and review articles which address current advancements related to the development of new procedures or protocols able to promote the repair or regeneration for all kinds of tissues using stem cell containing micrografts. Additionally, the special issue welcomes original basic research and review articles focusing on biological and cellular mechanisms involved in tissue repair or regeneration to better understand the key players activated in this process.

Potential topics include but are not limited to the following:

  • Stem cells in tissue engineering: micrografts, growth factors, biomaterials
  • Stem cell strategies for the management of nonhealing wounds
  • Advances in bone and cartilage regeneration using stem cells
  • New frontiers in cardiac regeneration
  • Biological, cellular, and anti-inflammatory mechanisms involved in tissue repair/regeneration

Articles

  • Special Issue
  • - Volume 2020
  • - Article ID 2195318
  • - Editorial

Promoting Tissue Repair by Micrograft Stem Cells Delivery

Letizia Trovato | Fabio Naro | ... | Federico Moreno
  • Special Issue
  • - Volume 2019
  • - Article ID 6461580
  • - Research Article

Activator Protein-1 Transcriptional Activity Drives Soluble Micrograft-Mediated Cell Migration and Promotes the Matrix Remodeling Machinery

Martina Balli | Jonathan Sai-Hong Chui | ... | Frederic Lluis
  • Special Issue
  • - Volume 2019
  • - Article ID 5043518
  • - Clinical Study

A Multicentre Study: The Use of Micrografts in the Reconstruction of Full-Thickness Posttraumatic Skin Defects of the Limbs—A Whole Innovative Concept in Regenerative Surgery

Michele Riccio | Andrea Marchesini | ... | Francesco De Francesco
  • Special Issue
  • - Volume 2019
  • - Article ID 5146594
  • - Clinical Study

Preenrichment with Adipose Tissue-Derived Stem Cells Improves Fat Graft Retention in Patients with Contour Deformities of the Face

Muhammad M. Bashir | Muhammad Sohail | ... | Mahmood S. Choudhery
  • Special Issue
  • - Volume 2019
  • - Article ID 7548160
  • - Research Article

A Three-Dimensional Culture Model of Reversibly Quiescent Myogenic Cells

Salvatore Aguanno | Claudia Petrelli | ... | Fabio Naro
  • Special Issue
  • - Volume 2019
  • - Article ID 8496025
  • - Research Article

Injectable Hydrogel Combined with Nucleus Pulposus-Derived Mesenchymal Stem Cells for the Treatment of Degenerative Intervertebral Disc in Rats

Feng Wang | Li-ping Nan | ... | Liang Zhang
  • Special Issue
  • - Volume 2019
  • - Article ID 8636079
  • - Research Article

A Retrospective Study on the Use of Dermis Micrografts in Platelet-Rich Fibrin for the Resurfacing of Massive and Chronic Full-Thickness Burns

Alessandro Andreone | Daan den Hollander
  • Special Issue
  • - Volume 2019
  • - Article ID 2168709
  • - Research Article

Transplantation of Human Urine-Derived Stem Cells Ameliorates Erectile Function and Cavernosal Endothelial Function by Promoting Autophagy of Corpus Cavernosal Endothelial Cells in Diabetic Erectile Dysfunction Rats

Chi Zhang | Daosheng Luo | ... | Guihua Liu
  • Special Issue
  • - Volume 2019
  • - Article ID 9843407
  • - Clinical Study

The Role of Autologous Dermal Micrografts in Regenerative Surgery: A Clinical Experimental Study

Marco Mario Tresoldi | Antonio Graziano | ... | Giovanni Nicoletti
Stem Cells International
 Journal metrics
Acceptance rate45%
Submission to final decision76 days
Acceptance to publication40 days
CiteScore3.800
Impact Factor3.902
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