Current research aims to investigate the interplay between stem cells and biomaterials for the repair and regeneration of tissues including bone, nerve, cartilage, dental tissues, liver, kidney, and so on. Stem cells meet dynamic microenvironments in our body and regulate tissue repair and regeneration. Various types of advanced biomaterials have been developed and fabricated as scaffolds to simulate the stem cell niche. Not only the composition of the niche, but also its mechanical properties such as stiffness, roughness, and osmotic cues have been imitated by engineering biomaterials.

Furthermore, stem cell behaviour can be efficiently modulated by incorporating bioactive molecules, for example, drugs, growth factors, exosomes, and metal ions, into biomaterials. Over the past few decades, promising clinical outcomes have clearly indicated synergistic effects of the combination of biomaterials and stem cell therapy on tissue regeneration. For successful clinical application of biomaterials and stem cells, it has become more important to develop large-scale tissue engineering platforms such as an automatic biomanufacturing system, ex vivo cell expansion platform, and so on.

This Special Issue therefore invites multidisciplinary contributions from original research articles focusing on recent progress on the interplay between biomaterials and stem cells for the repair and regeneration of various tissues as well as biomanufacturing platforms for stem cell therapy. Review articles that describe the current state of the art are also welcome.

Potential topics include but are not limited to the following:

• Studies of the interplay between stem cells and biomaterials for tissue regeneration
• In vitro, ex vivo, and translational studies of stem cell therapies for tissue regeneration with biomaterials
• Studies of the tissue regenerative mechanisms using stem cells or biomaterials
• Novel investigations based on tissue engineering, platform, manufacturing, machine learning, artificial intelligence, genomics, and bioinformatics for understanding stem cells and biomaterials
• Preclinical trials of stem cell therapies using biomaterials for post-injury connective tissue regeneration