Stem Cells International

Advances and New Technologies Towards Clinical Application of Oral Stem Cells and Their Secretome


Publishing date
17 Feb 2017
Status
Published
Submission deadline
30 Sep 2016

Lead Editor

1Aix-Marseille University, Marseille, France

2Aristotle University of Thessaloniki, Thessaloniki, Greece

3University of Tennessee, Knoxville, USA

4Medical University of Hannover, Hannover, Germany

5University of Laval, Québec City, Canada


Advances and New Technologies Towards Clinical Application of Oral Stem Cells and Their Secretome

Description

Oral and dental diseases are major public health problems worldwide, with a profound effect on quality of life. Recent progress in tissue engineering has raised great hopes for innovative alternative therapies based on regeneration strategies of tissues in the whole craniofacial area. The discovery and characterization of stem cells (SCs) from various oral sources together with the cutting edge research of recent years in understanding their biology have enhanced our knowledge of the complex role of SCs in developmental/repair processes. The application of this knowledge in translational studies has been a decisive milestone in bringing these technologies closer to clinical application. Amazing technological advances have provided valuable tools in translating scientific advances into clinical settings. Finally, establishment of good manufacturing practice-GMP protocols according to European regulations has facilitated feasibility and “proof-of-concept” clinical trials on the application of oral SCs in orofacial tissue regeneration. Most recently, the possibility of using the plethora of secreted throphic and immunomodulatory cytokines produced by SCs (secretome) as a therapeutic surrogate module for cells has been proposed as a safer alternative to stem cell transplantation, raising the therapeutic dilemma: stem cell or secretome therapy?

We are soliciting high quality original research as well as review articles focusing on advances and new technologies towards understanding the activation, recruitment, and clinical application of oral SCs and their secretome.

Potential topics include but are not limited to the following:

  • Translational research towards regeneration of various oral tissues, such as dental (dentin, pulp, and periodontal ligament), orofacial bones, salivary glands, oral mucosa, and temporomandibular joint condylar cartilage
  • Application of oral SCs to other areas of medicine, such as revascularization/reinnervation of damaged tissues and regeneration of muscle, bone, tendon, cartilage, or other tissues, such as cornea (e.g., using oral epithelial SCs), and pancreas (e.g., using salivary gland SCs)
  • Topics related to new technologies for oral tissue regeneration, such as design of novel, customized scaffolds by means of bioprinting, optimization of microenvironments using bioreactor technologies, and single cell or whole niche analysis by microfluidics or other relevant topics
  • Clinical research on application of oral SCs and their secretome, including feasibility and “proof-of-concept” studies, new methodological paradigms that challenge current thinking in clinical research, and development of clinical-grade oral SCs under GMP conditions as an essential step towards clinical application or other relevant topics

Articles

  • Special Issue
  • - Volume 2017
  • - Article ID 6367375
  • - Editorial

Advances and New Technologies towards Clinical Application of Oral Stem Cells and Their Secretome

Athina Bakopoulou | George T.-J. Huang | ... | Imad About
  • Special Issue
  • - Volume 2016
  • - Article ID 7564689
  • - Review Article

Three-Dimensional Bioprinting Nanotechnologies towards Clinical Application of Stem Cells and Their Secretome in Salivary Gland Regeneration

Joao N. Ferreira | Sasitorn Rungarunlert | ... | Glauco R. Souza
  • Special Issue
  • - Volume 2016
  • - Article ID 6205910
  • - Clinical Study

Phase I/II Trial of Autologous Bone Marrow Stem Cell Transplantation with a Three-Dimensional Woven-Fabric Scaffold for Periodontitis

Shunsuke Baba | Yoichi Yamada | ... | Sayaka Nakamura
  • Special Issue
  • - Volume 2016
  • - Article ID 4209891
  • - Review Article

Stem Cells of Dental Origin: Current Research Trends and Key Milestones towards Clinical Application

Athina Bakopoulou | Imad About
  • Special Issue
  • - Volume 2016
  • - Article ID 6921097
  • - Research Article

Characterization of Neurogenic Potential of Dental Pulp Stem Cells Cultured in Xeno/Serum-Free Condition: In Vitro and In Vivo Assessment

Jieun Jung | Jong-Wan Kim | ... | Jung Keun Hyun
  • Special Issue
  • - Volume 2016
  • - Article ID 9762871
  • - Review Article

The Neurovascular Properties of Dental Stem Cells and Their Importance in Dental Tissue Engineering

Jessica Ratajczak | Annelies Bronckaers | ... | Petra Hilkens
  • Special Issue
  • - Volume 2016
  • - Article ID 8596520
  • - Research Article

Comparison of Stemness and Gene Expression between Gingiva and Dental Follicles in Children

Chung-Min Kang | Seong-Oh Kim | ... | Jae-Ho Lee
  • Special Issue
  • - Volume 2016
  • - Article ID 1947157
  • - Research Article

Investigation of the Cell Surface Proteome of Human Periodontal Ligament Stem Cells

Jimin Xiong | Danijela Menicanin | ... | Stan Gronthos
  • Special Issue
  • - Volume 2016
  • - Article ID 7154327
  • - Review Article

Gingival Mesenchymal Stem/Progenitor Cells: A Unique Tissue Engineering Gem

Karim M. Fawzy El-Sayed | Christof E. Dörfer
  • Special Issue
  • - Volume 2016
  • - Article ID 1290561
  • - Research Article

Clonal Heterogeneity in the Neuronal and Glial Differentiation of Dental Pulp Stem/Progenitor Cells

Fraser I. Young | Vsevolod Telezhkin | ... | Bing Song
Stem Cells International
 Journal metrics
Acceptance rate45%
Submission to final decision76 days
Acceptance to publication35 days
CiteScore3.800
Impact Factor3.902
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