Stem cells, including pluripotent stem cells and adult stem cells, hold great potential. They possess the ability to differentiate into specialized cell types that can be widely utilized in cell therapy, drug discovery and regenerative medicine. Hence, tremendous efforts have been put into comprehending the epigenetic regulatory mechanism in stem cell differentiation.

The aim of this Special Issue is to collate original research articles as well as review articles that will stimulate the continuing efforts in stem cell differentiation. We are interested in articles describing new mechanisms of chromatin regulation, related gene regulatory strategies and novel applications of chromatin regulation in stem cell differentiation.

Potential topics include but are not limited to the following:

• New molecular mechanisms of histone modifications during stem cell differentiation
• Role of DNA (de)methylation in stem cell differentiation
• Novel chromatin co-activators/co-repressors in stem cell differentiation
• Recent findings of chromatin remodelling in stem cell differentiation
• Recent developments in methods of chromatin regulation
• Recent applications of chromatin regulation in controlling stem cell differentiation
• Animal models used in studying chromatin regulation in stem cell differentiation