Stem Cells International

MSCs: Scientific Support for Multiple Therapies


Status
Published

1University of Maryland School of Medicine, Baltimore, USA

2Karolinska Institute, Stockholm, Sweden

3The Scripps Research Institute, Jupiter, USA

4NUS/Duke-National University Hospital, Singapore


MSCs: Scientific Support for Multiple Therapies

Description

Whether we call them Mesenchymal Stem Cells, Mesenchymal Stromal Cells, Multipotential Stromal Cells, Skeletal Stem Cells, or another name, this class of multipotent progenitor cells has been continuously studied for more than 20 years. After more than 20,000 papers on MSCs, it is important that the field establish benchmarks and consensus procedures that can lead to effective therapies. Importantly, the first autologous in vitro cultured MSCs were injected into recipients over two decades ago. Today, over 300 clinical trials have been initiated with MSC or MSC-like cellular therapeutics and clinical results continue to accumulate. However, there are questions related to many aspects of MSC science and clinical therapy that need further clarification and confirmation. For this special issue of Stem Cells International, we invite investigators to submit original research articles related to MSC science and therapeutics that will further stimulate the scientific community effort to understand and utilize these multipotential cells. We are particularly interested in new approaches with sound scientific basis that elucidate basic MSC processes, and MSC therapies that have a clear benefit or provide therapeutic improvement. Focused, concise reviews will be considered but authors should write to the editors before submitting.

Potential topics include, but are not limited to:

  • miRNAs as MSC regulators
  • Therapies where none existed before: but much promise
  • Taking MSCs from the dish to the body
  • MSC and interactions
  • Improving MSC survival once delivered
  • Use of MSCs in bone repair: forgotten or common practice
  • Where have all the MSCs gone? Can vanishingly small numbers of MSCs provide lasting clinical benefit?
  • MSC : stem cell fault or feature
  • Does anyone really have a better MSC and how do we evaluate the claim?

Articles

  • Special Issue
  • - Volume 2015
  • - Article ID 280572
  • - Editorial

MSCs: Scientific Support for Multiple Therapies

Mark F. Pittenger | Katarina Le Blanc | ... | Jerry K. Y. Chan
  • Special Issue
  • - Volume 2015
  • - Article ID 306158
  • - Research Article

Comparisons of Differentiation Potential in Human Mesenchymal Stem Cells from Wharton’s Jelly, Bone Marrow, and Pancreatic Tissues

Shih-Yi Kao | Jia-Fwu Shyu | ... | Pei-Jiun Tsai
  • Special Issue
  • - Volume 2015
  • - Article ID 914632
  • - Review Article

Multipotent Mesenchymal Stromal Cells: Possible Culprits in Solid Tumors?

Pascal David Johann | Ingo Müller
  • Special Issue
  • - Volume 2015
  • - Article ID 895714
  • - Review Article

Bottlenecks in the Efficient Use of Advanced Therapy Medicinal Products Based on Mesenchymal Stromal Cells

Natalia Escacena | Elena Quesada-Hernández | ... | Abdelkrim Hmadcha
  • Special Issue
  • - Volume 2015
  • - Article ID 640218
  • - Research Article

Modulation of Hyaluronan Synthesis by the Interaction between Mesenchymal Stem Cells and Osteoarthritic Chondrocytes

Eliane Antonioli | Carla A. Piccinato | ... | Mario Ferretti
  • Special Issue
  • - Volume 2015
  • - Article ID 628767
  • - Review Article

Adult Mesenchymal Stem Cells: When, Where, and How

Arnold I. Caplan
  • Special Issue
  • - Volume 2015
  • - Article ID 375187
  • - Review Article

Regenerative Translation of Human Blood-Vessel-Derived MSC Precursors

William C. W. Chen | Bruno Péault | Johnny Huard
  • Special Issue
  • - Volume 2015
  • - Article ID 974864
  • - Review Article

Low Reactive Level Laser Therapy for Mesenchymal Stromal Cells Therapies

Toshihiro Kushibiki | Takeshi Hirasawa | ... | Miya Ishihara
Stem Cells International
 Journal metrics
Acceptance rate44%
Submission to final decision76 days
Acceptance to publication35 days
CiteScore7.200
Impact Factor3.869
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