Stem Cells International

Skeletal Muscle Cells Generated from Pluripotent Stem Cells


Status
Published

1National Center of Neurology and Psychiatry, Tokyo, Japan

2University of Minnesota, Minneapolis, USA

3University of Wisconsin-Madison, Madison, USA


Skeletal Muscle Cells Generated from Pluripotent Stem Cells

Description

Human ES/iPS cells (hES/iPSCs) are a powerful tool for in vitro disease modeling and are expected to be a promising cell source for cell therapy targeting many degenerative diseases including muscular dystrophies. At present, however, derivation of skeletal muscle stem cells/progenitors with high regenerative potential from hES/iPSCs is still challenging. In addition, in vitro generated hES/iPSC-derived myofibers are morphologically and functionally less mature than postnatal myofibers. In this special issue, we would like to summarize the current status of research progress on ES/iPSC-based disease modelling and ES/iPSC-based cell therapy, discuss what the barriers are for the successful induction of skeletal muscle suitable for regenerative medicine and ES/iPSC-based drug development, and collect technical tips for in vitro disease modeling and ES/iPSC-based regenerative medicine.

We welcome animal derived-ES/iPSC. We also welcome both a comprehensive review article and an original cutting-edge research article describing a novel finding on muscle differentiation of ES/iPSCs, which would improve protocols for skeletal muscle cell induction from ES/iPSCs. We also accept a manuscript describing studies which has been well-planned and correctly performed but failed to be published in a top-journal due to negative data.

Potential topics include but are not limited to the following:

  • Biomaterials for 3D culture of ES/iPSC-derived skeletal muscle
  • In vitro modeling of human diseases using patient-derived cells or gene-edited ES/iPSCs
  • iPSC-mediated high throughput screening of small molecules which reverse disease phenotypes
  • Methods for deviation of highly regenerative skeletal muscle stem cells/progenitor cells from ES/iPSCs
  • Purification of ES/iPSC-derived skeletal muscle stem cells/progenitors for safe and efficient cell therapy
  • Efficient transplantation methods of ES/iPSC-derived skeletal muscle stem cells/progenitors
  • Induction of tumor-free ES/iPSC-derived skeletal muscle stem cells/progenitors
  • Evaluation of safe transplantable ES/iPSC-derived skeletal muscle stem cells/progenitors

Articles

  • Special Issue
  • - Volume 2017
  • - Article ID 7824614
  • - Editorial

Skeletal Muscle Cells Generated from Pluripotent Stem Cells

Yuko Miyagoe-Suzuki | Atsushi Asakura | Masatoshi Suzuki
  • Special Issue
  • - Volume 2017
  • - Article ID 7541734
  • - Research Article

Can Human Embryonic Stem Cell-Derived Stromal Cells Serve a Starting Material for Myoblasts?

Yu Ando | Marie Saito | ... | Akihiro Umezawa
  • Special Issue
  • - Volume 2017
  • - Article ID 8765154
  • - Review Article

Cellular Reprogramming, Genome Editing, and Alternative CRISPR Cas9 Technologies for Precise Gene Therapy of Duchenne Muscular Dystrophy

Peter Gee | Huaigeng Xu | Akitsu Hotta
  • Special Issue
  • - Volume 2017
  • - Article ID 1376151
  • - Review Article

Skeletal Muscle Cell Induction from Pluripotent Stem Cells

Yusaku Kodaka | Gemachu Rabu | Atsushi Asakura
  • Special Issue
  • - Volume 2017
  • - Article ID 7906843
  • - Research Article

Induction of Pluripotent Stem Cells from a Manifesting Carrier of Duchenne Muscular Dystrophy and Characterization of Their X-Inactivation Status

Yuko Miyagoe-Suzuki | Takashi Nishiyama | ... | Shin’ichi Takeda
  • Special Issue
  • - Volume 2017
  • - Article ID 7215010
  • - Review Article

Epigenetic Manipulation Facilitates the Generation of Skeletal Muscle Cells from Pluripotent Stem Cells

Tomohiko Akiyama | Shunichi Wakabayashi | ... | Minoru S. H. Ko
  • Special Issue
  • - Volume 2017
  • - Article ID 9210494
  • - Research Article

Myogenic Differentiation from MYOGENIN-Mutated Human iPS Cells by CRISPR/Cas9

Koki Higashioka | Noriko Koizumi | ... | Takahiko Sato
Stem Cells International
 Journal metrics
Acceptance rate44%
Submission to final decision76 days
Acceptance to publication35 days
CiteScore7.200
Impact Factor3.869
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