Stem Cells International

Bone Microenvironment, Stem Cells, and Bone Tissue Regeneration


Publishing date
16 Sep 2016
Status
Published
Submission deadline
29 Apr 2016

Lead Editor

1University of Sydney, Sydney, Australia

2University of Amsterdam, Amsterdam, Netherlands

3Soochow University, Suzhou, China


Bone Microenvironment, Stem Cells, and Bone Tissue Regeneration

Description

Stem cell-based bone tissue engineering offers a promising approach for regenerating critical sized bone defects or repairing nonunion bone fracture. Understanding and recreating a signalling environment to control the differentiation of stem cells into the bone lineage would be of great importance. The components in bone microenvironment, which include a mineral phase (hydroxyapatite nanocrystals), an organic phase (composed of 90% collagen type I), a cellular phase (osteoblasts, osteoclasts, and osteocytes), and a soluble factor phase (growth factors and/or cytokines), provide a specific and balanced signalling network, which contribute to the innate bone metabolic and anabolic activities and maintain the structure and functions of the bone. Substantial efforts, therefore, are needed to mimic the bone tissue microenvironmental components for controlling the commitment of stem cells into osteogenic lineage cells for bone tissue regeneration.

In this special issue, we invite investigators to contribute original research as well as review articles related to priming stem cell fate into the osteogenic lineage via mimicking the components of the bone microenvironment.

Potential topics include, but are not limited to:

  • Biomaterials mimicking chemical and/or physical characteristics of the bone extracellular matrix (ECM) such as molecular, architectural, topographical, and mechanical properties
  • Biomechanical stimulations mimicking the innate mechanical environment of bone tissue, such as mechanical loading and fluid flow
  • Cell-cell cross talk, such as osteoblast- (or osteocyte-) stem cell and macrophage-stem cell interactions
  • Growth factors or cytokines which provide instructive cues for directing stem cells differentiation into bone lineage
  • Signalling pathways underlying osteogenesis and their synergy of directing stem cells into osteogenic lineage
  • Novel tissue engineering approaches for bone regeneration, such as cell sheet-based scaffold-free technologies

Articles

  • Special Issue
  • - Volume 2017
  • - Article ID 1315243
  • - Editorial

Bone Microenvironment, Stem Cells, and Bone Tissue Regeneration

ZuFu Lu | Jenneke Kleine-Nulend | Bin Li
  • Special Issue
  • - Volume 2017
  • - Article ID 4045238
  • - Review Article

Osteopontin: Relation between Adipose Tissue and Bone Homeostasis

Carolina De Fusco | Antonietta Messina | ... | Giovanni Messina
  • Special Issue
  • - Volume 2016
  • - Article ID 7403890
  • - Research Article

Implant Composed of Demineralized Bone and Mesenchymal Stem Cells Genetically Modified with AdBMP2/AdBMP7 for the Regeneration of Bone Fractures in Ovis aries

Adelina A. Hernandez-Hurtado | Gissela Borrego-Soto | ... | Augusto Rojas-Martinez
  • Special Issue
  • - Volume 2016
  • - Article ID 3187491
  • - Review Article

Mesenchymal Stem Cells Subpopulations: Application for Orthopedic Regenerative Medicine

Vanessa Pérez-Silos | Alberto Camacho-Morales | Lizeth Fuentes-Mera
  • Special Issue
  • - Volume 2016
  • - Article ID 1416047
  • - Research Article

Slowly Delivered Icariin/Allogeneic Bone Marrow-Derived Mesenchymal Stem Cells to Promote the Healing of Calvarial Critical-Size Bone Defects

Tianlin Liu | Xin Zhang | ... | Gang Wu
  • Special Issue
  • - Volume 2016
  • - Article ID 1318256
  • - Research Article

Cytokines TNF-α, IL-6, IL-17F, and IL-4 Differentially Affect Osteogenic Differentiation of Human Adipose Stem Cells

Angela P. Bastidas-Coral | Astrid D. Bakker | ... | Jenneke Klein-Nulend
  • Special Issue
  • - Volume 2016
  • - Article ID 1934270
  • - Research Article

Enhanced Osteogenic and Vasculogenic Differentiation Potential of Human Adipose Stem Cells on Biphasic Calcium Phosphate Scaffolds in Fibrin Gels

Fransisca A. S. van Esterik | Behrouz Zandieh-Doulabi | ... | Jenneke Klein-Nulend
  • Special Issue
  • - Volume 2016
  • - Article ID 8792191
  • - Research Article

Bone Formation from Porcine Dental Germ Stem Cells on Surface Modified Polybutylene Succinate Scaffolds

Nergis Abay | Gorke Gurel Pekozer | ... | Gamze Torun Kose
  • Special Issue
  • - Volume 2016
  • - Article ID 8741641
  • - Research Article

Restoration of a Critical Mandibular Bone Defect Using Human Alveolar Bone-Derived Stem Cells and Porous Nano-HA/Collagen/PLA Scaffold

Xing Wang | Helin Xing | ... | Hongchen Liu
  • Special Issue
  • - Volume 2016
  • - Article ID 7130653
  • - Research Article

Naringin Stimulates Osteogenic Differentiation of Rat Bone Marrow Stromal Cells via Activation of the Notch Signaling Pathway

Guo-yong Yu | Gui-zhou Zheng | ... | Xue-dong Li
Stem Cells International
 Journal metrics
Acceptance rate45%
Submission to final decision76 days
Acceptance to publication35 days
CiteScore3.800
Impact Factor3.902
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