Stem Cells International

Clinical Perspectives of Mesenchymal Stem Cells


Publishing date
30 Jun 2012
Status
Published
Submission deadline
30 Dec 2011

Lead Editor

1Medical Department I, Interdisciplinary Group Stem Cell Biology and Transplantation Unit, University of Lübeck, Ratzeburger Allee 160, 23538 Lübeck, Germany

2Kennedy Institute of Rheumatology, Imperial College London, 65 Aspenlea Road, London W6 8LH, UK

3Laboratory of Cell Biology and Advanced Cancer Therapies,Department of Oncology, Hematology and Respiratory Diseases, University Hospital of Modena and Reggio Emilia, Via del Pozzo, 71, 41100 Modena, Italy

4Institute of Transfusion Medicine and Transplantation Immunology, University of Münster, Domagkstrasse 11, 48149 Münster, Germany

5Institute of Biomedical Technologies, Stem Cell Biology and Cellular Engineering, RWTH Aachen University Medical School, Pauwelsstraße 20, 52074 Aachen, Germany


Clinical Perspectives of Mesenchymal Stem Cells

Description

Mesenchymal stem cells (MSCs) comprise a subpopulation with multipotent differentiation capacity. Their culture has been established in the early 1960s when fibroblastoid cells were discussed as supportive stromal cells within the hematopoietic bone marrow niche. Initially, application of MSC was based on the hope to cure defects of cartilage or bone. Later, MSCs were also administered in myocardial infarction or in diseases of the central nervous system as well as in liver or kidney failure. Varying outcomes in these studies might be a result of the heterogeneity of MSC cultures and due to absence of reliable protocols for isolation of the naïve stem cell. However, the immunomodulatory function of MSC resulted in further clinical perspectives: studies have demonstrated that human MSCs reduce allorecognition, interfere with antigen-presenting cells and T-cell function, and generate a local immunosuppressive microenvironment by cytokines. This paved the way for MSC-based treatment of autoimmune diseases and graft-versus-host disease after HLA-mismatched allogeneic hematopoietic stem cell transplantation.

This special issue will become an international forum to summarize recent developments in MSC biology and clinical research. We especially ask for manuscripts that describe molecular characteristics of MSCs or their application in animal models or clinical trials. Reviews that summarize the results of basic research with clinical impact are also welcome. Potential topics include, but are not limited to:

  • Optimization of MSC isolation, characterization, and expansion
  • Basic research: studies on MSC biology
  • Preclinical research: application of MSC in animal models of diseases
  • Clinical research: background and results of studies about MSC application in humans

Before submission authors should carefully read over the journal's Author Guidelines, which are located at http://www.hindawi.com/journals/sci/guidelines/. Prospective authors should submit an electronic copy of their complete manuscript through the journal Manuscript Tracking System at http://mts.hindawi.com/ according to the following timetable:


Articles

  • Special Issue
  • - Volume 2012
  • - Article ID 684827
  • - Editorial

Clinical Perspectives of Mesenchymal Stem Cells

Jan Kramer | Francesco Dazzi | ... | Wolfgang Wagner
  • Special Issue
  • - Volume 2012
  • - Article ID 303610
  • - Clinical Study

Optimization of Parameters for a More Efficient Use of Adipose-Derived Stem Cells in Regenerative Medicine Therapies

Meire Aguena | Roberto Dalto Fanganiello | ... | Maria Rita Passos-Bueno
  • Special Issue
  • - Volume 2012
  • - Article ID 931902
  • - Clinical Study

Bilateral Transplantation of Allogenic Adult Human Bone Marrow-Derived Mesenchymal Stem Cells into the Subventricular Zone of Parkinson’s Disease: A Pilot Clinical Study

N. K. Venkataramana | Rakhi Pal | ... | Krishna Chaitanya
  • Special Issue
  • - Volume 2012
  • - Article ID 980353
  • - Review Article

Mesenchymal Stem Cells as a Potent Cell Source for Bone Regeneration

Elham Zomorodian | Mohamadreza Baghaban Eslaminejad
  • Special Issue
  • - Volume 2012
  • - Article ID 175979
  • - Review Article

Mesenchymal Stem Cells and Cardiovascular Disease: A Bench to Bedside Roadmap

Manuel Mazo | Miriam Araña | ... | Felipe Prosper
  • Special Issue
  • - Volume 2012
  • - Article ID 968213
  • - Clinical Study

Multipotent Mesenchymal Stromal Cells for the Prophylaxis of Acute Graft-versus-Host Disease—A Phase II Study

Larisa A. Kuzmina | Natalia A. Petinati | ... | Valery G. Savchenko
  • Special Issue
  • - Volume 2012
  • - Article ID 920581
  • - Research Article

Multipotent Mesenchymal Stromal Stem Cell Expansion by Plating Whole Bone Marrow at a Low Cellular Density: A More Advantageous Method for Clinical Use

Katia Mareschi | Deborah Rustichelli | ... | Franca Fagioli
Stem Cells International
 Journal metrics
Acceptance rate44%
Submission to final decision76 days
Acceptance to publication35 days
CiteScore7.200
Impact Factor3.869
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