Stem Cells International

Adult Stem Cells in Tissue Maintenance and Regeneration


Publishing date
01 Jan 2016
Status
Published
Submission deadline
14 Aug 2015

1University of Naples "Federico II", Naples, Italy

2University Hospital of Cologne, Cologne, Germany

3Tokai University Institute of Innovative Science and Technology, Kanagawa, Japan

4University of Naples “Federico II”, Naples, Italy


Adult Stem Cells in Tissue Maintenance and Regeneration

Description

Research on adult stem cells has recently generated a great deal of excitement. Somatic stem cells have been found in many human tissues; notwithstanding a low abundance in adult, their role is to sustain the function of an organ despite its physiological wear and tear or aging and to allow the regeneration in disease or injury. Our increasing ability to identify and isolate tissue-specific stem cells and the comprehension of mechanisms controlling their self-renewal and differentiation in vitro and in vivo offer possibility of replenishing cells damaged by disease, exploited by regenerative medicine. Intriguingly, blood and bone marrow-derived multipotent stem cells or induced pluripotent stem cells, even though they are relatively numerous and easy to isolate and propagate, have not yet proved clinically successful in reconstituting cells in adult human organs. Possibly, tissue-specific biological cues that determine the fate of adult stem cells and committed progenitors in normal and pathological conditions pose limits to cell plasticity and differentiation in vivo.

Hence, our understanding of adult tissue-specific stem cell biology can provide the basis for experimental and therapeutical tissue regeneration. While this knowledge is expanding, the abundance and ever growing number of original research articles, which always pose new questions rather than yield conclusive answers, are a call for the need to summarize information and gather the perspective necessary to focus the interests and direct future scientific efforts towards the clinical application. The ultimate goal of such action would be to provide both basic science and clinical researchers in different stages of their career with the multidisciplinary platform for expanding their understanding of tissue and organ biology and how best to implement organ regenerative potential in clinical practice.

For this purpose, we invite authors to submit comprehensive and concise review articles summarizing the current notion of tissue regeneration and reporting up-to-date knowledge on topics related to tissue-specific stem cells in adult organs, such as the heart, lung, liver, intestine, kidney, brain, or skin.

Potential topics include, but are not limited to:

  • Histological identification and localization of stem cells within organ
  • Cellular and molecular characteristics of adult stem cells and their microenvironment
  • Factors regulating somatic stem cell fate and differentiation
  • Isolation, propagation, characterization, and maturation of adult stem cells in vitro
  • Application of knowledge related to tissue-specific adult stem cells to human disease and therapy

Articles

  • Special Issue
  • - Volume 2016
  • - Article ID 7362879
  • - Editorial

Adult Stem Cells in Tissue Maintenance and Regeneration

Stefania Montagnani | Maria A. Rueger | ... | Daria Nurzynska
  • Special Issue
  • - Volume 2016
  • - Article ID 3658013
  • - Review Article

Stem/Progenitor Cell Niches Involved in Hepatic and Biliary Regeneration

Guido Carpino | Anastasia Renzi | ... | Eugenio Gaudio
  • Special Issue
  • - Volume 2016
  • - Article ID 9010279
  • - Research Article

Adipose-Derived Mesenchymal Stem Cells in the Regeneration of Vocal Folds: A Study on a Chronic Vocal Fold Scar

Angelou Valerie | Kalodimou Vassiliki | ... | Papalois Apostolos
  • Special Issue
  • - Volume 2016
  • - Article ID 2171035
  • - Review Article

Cell Therapy in Ischemic Heart Disease: Interventions That Modulate Cardiac Regeneration

Maximiliano I. Schaun | Bruna Eibel | ... | Melissa M. Markoski
  • Special Issue
  • - Volume 2016
  • - Article ID 5395261
  • - Research Article

Comparison of Signaling Pathways Gene Expression in CD34 Umbilical Cord Blood and Bone Marrow Stem Cells

Rafał Stojko | Monika Bojdys-Szyndlar | ... | Krzysztof Wilk
  • Special Issue
  • - Volume 2016
  • - Article ID 4285215
  • - Review Article

Mesenchymal Stromal Cells and Tissue-Specific Progenitor Cells: Their Role in Tissue Homeostasis

Aleksandra Klimczak | Urszula Kozlowska
  • Special Issue
  • - Volume 2016
  • - Article ID 5687589
  • - Research Article

A Member of the Nuclear Receptor Superfamily, Designated as NR2F2, Supports the Self-Renewal Capacity and Pluripotency of Human Bone Marrow-Derived Mesenchymal Stem Cells

Ni Zhu | Huafang Wang | ... | He Huang
  • Special Issue
  • - Volume 2016
  • - Article ID 4709572
  • - Review Article

Mesenchymal Stem Cells Derived from Dental Pulp: A Review

Edgar Ledesma-Martínez | Víctor Manuel Mendoza-Núñez | Edelmiro Santiago-Osorio
  • Special Issue
  • - Volume 2016
  • - Article ID 6120173
  • - Review Article

Insight into Reepithelialization: How Do Mesenchymal Stem Cells Perform?

Deyun Chen | Haojie Hao | ... | Weidong Han
Stem Cells International
 Journal metrics
Acceptance rate45%
Submission to final decision76 days
Acceptance to publication35 days
CiteScore3.800
Impact Factor3.902
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