Stem Cells International

Aryl Hydrocarbon Receptor and Stem Cells


Status
Published

1University of Rochester, Rochester, USA

2Pontifical Catholic University of Peru, Lima, Peru


Aryl Hydrocarbon Receptor and Stem Cells

Description

The aryl hydrocarbon receptor (AhR) is a highly conserved, developmentally regulated, and ligand-activated member of bHLH/PAS family of transcription factors. Accumulating data indicates that it plays an important role in variety of developmental and physiological functions. The AhR is present in cytosol as component of multiprotein complex containing the immunophilin-like protein XAP2/AIP/ARA9, the 23-kDa co-chaperone protein p23, and two molecule of hsp90. The aryl hydrocarbon receptor is originally identified as mediating the toxicity of a large group of xenobiotics. These xenobiotic ligands have potent and persistent effects on the immune system in experimental animal models. Epidemiological studies have linked human exposure to environmental AhR ligands with increased incidence of lymphoma and leukemia. AhR plays significant roles in physiological functions of stem cells of various tissue origins. This research area has been identified recently. We invite overview and original papers describing current development in the area of AhR role in stem cell functions. Both experimental and review papers are welcome.

Potential topics include, but are not limited to:

  • AhR and hematopoietic stem cells
  • AhR and megakaryocytic differentiation
  • AhR and induced pluripotent cells
  • AhR and neuronal development
  • AhR and liver stem cells
  • AhR and skin stem cells
  • Environmental chemicals and stem cells
  • Stem cells as model of drug discovery and toxicological evaluation
  • AhR and cancer

Articles

  • Special Issue
  • - Volume 2017
  • - Article ID 4602854
  • - Editorial

Aryl Hydrocarbon Receptor and Stem Cells

Thomas A. Gasiewicz | Kameshwar P. Singh | Fanny L. Casado
  • Special Issue
  • - Volume 2016
  • - Article ID 1753491
  • - Research Article

PAHs Target Hematopoietic Linages in Bone Marrow through Cyp1b1 Primarily in Mesenchymal Stromal Cells but Not AhR: A Reconstituted In Vitro Model

Catherine M. Rondelli | Michele Campaigne Larsen | ... | Colin R. Jefcoate
  • Special Issue
  • - Volume 2016
  • - Article ID 7943495
  • - Review Article

Antioxidant Functions of the Aryl Hydrocarbon Receptor

Cornelia Dietrich
  • Special Issue
  • - Volume 2016
  • - Article ID 4389802
  • - Review Article

The Aryl Hydrocarbon Receptor Relays Metabolic Signals to Promote Cellular Regeneration

Fanny L. Casado
  • Special Issue
  • - Volume 2016
  • - Article ID 4536187
  • - Research Article

Aryl Hydrocarbon Receptor Deficiency in an Exon 3 Deletion Mouse Model Promotes Hematopoietic Stem Cell Proliferation and Impacts Endosteal Niche Cells

Zeenath Unnisa | Kameshwar P. Singh | ... | Thomas A. Gasiewicz
  • Special Issue
  • - Volume 2016
  • - Article ID 4326194
  • - Review Article

Environmental Ligands of the Aryl Hydrocarbon Receptor and Their Effects in Models of Adult Liver Progenitor Cells

Jan Vondráček | Miroslav Machala
  • Special Issue
  • - Volume 2016
  • - Article ID 2574152
  • - Research Article

Genome Editing of the CYP1A1 Locus in iPSCs as a Platform to Map AHR Expression throughout Human Development

Brenden W. Smith | Elizabeth A. Stanford | ... | George J. Murphy
Stem Cells International
 Journal metrics
Acceptance rate44%
Submission to final decision76 days
Acceptance to publication35 days
CiteScore7.200
Impact Factor3.869
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