Stem Cells International

Stem Cell-Based Therapy in Transplantation and Immune-Mediated Diseases


Status
Published

1University of Kragujevac, Kragujevac, Serbia

2University of Newcastle, Newcastle, UK

3Principe Felipe Research Center, Valencia, Spain

4Spebo Medical, Leskovac, Serbia


Stem Cell-Based Therapy in Transplantation and Immune-Mediated Diseases

Description

The results achieved in stem cell research during the last decades demonstrate rapid progress and the increased importance of stem cells in both basic research and the long-term future of modern medicine. Stem cell research has become a highly vigorous and rapidly evolving field in life sciences after the discovery of induced pluripotent stem cells (iPSCs), reprogrammed adult cells. With the remarkable capacity of self-renewal and differentiation into more specialized cell lineages, iPSCs constitute a promising resource in transplantation and regenerative medicine, while, due to their immune-modulatory characteristics, mesenchymal stem cells (MSCs) are an attractive option for improving the treatment of immune-mediated disorders.

However, it is important to highlight the fact that despite the enormous scientific progress in this field, there are no stem cells that provide a cure for everything and everyone. Thus, the research process should foster ever closer dialogue between basic researches and clinical investigation protocols in order to improve bench-to-bedside translation of stem cell therapies. Accordingly, in this special issue, we invite investigators to contribute with original research articles as well as review articles that may provide novel insights in this field.

Potential topics include but are not limited to the following:

  • Cellular and molecular mechanisms involved in MSC-based treatment of immune-mediated diseases
  • Organ specific stem cells: a new hope in transplantation medicine
  • MSC-mediated modulation of local and systemic inflammation
  • Human iPSCs as a platform for transplantation medicine
  • Stem cell-mediated control of crosstalk between angiogenesis and inflammation in tissue repair
  • Stem cells and tissue engineering: new approaches to accelerate bench-to-bedside transition after organ transplantation
  • Strategies for overcoming limitations of MSC-based modulation of immune response
  • Stem cells and organ transplantation: opportunities and challenges

Articles

  • Special Issue
  • - Volume 2017
  • - Article ID 7379136
  • - Editorial

Stem Cell-Based Therapy in Transplantation and Immune-Mediated Diseases

Vladislav Volarevic | Majlinda Lako | ... | Miodrag Stojkovic
  • Special Issue
  • - Volume 2017
  • - Article ID 1315378
  • - Research Article

Mesenchymal Stem Cells Attenuate Cisplatin-Induced Nephrotoxicity in iNOS-Dependent Manner

Bojana Simovic Markovic | Marina Gazdic | ... | Vladislav Volarevic
  • Special Issue
  • - Volume 2017
  • - Article ID 6294717
  • - Research Article

Mesenchymal Stem Cells Promote Metastasis of Lung Cancer Cells by Downregulating Systemic Antitumor Immune Response

Marina Gazdic | Bojana Simovic Markovic | ... | Vladislav Volarevic
  • Special Issue
  • - Volume 2017
  • - Article ID 2353240
  • - Research Article

Crosstalk with Inflammatory Macrophages Shapes the Regulatory Properties of Multipotent Adult Progenitor Cells

Stylianos Ravanidis | Jeroen F. J. Bogie | ... | Niels Hellings
  • Special Issue
  • - Volume 2017
  • - Article ID 4758930
  • - Research Article

Human Suprapatellar Fat Pad-Derived Mesenchymal Stem Cells Induce Chondrogenesis and Cartilage Repair in a Model of Severe Osteoarthritis

Ignacio Muñoz-Criado | Jose Meseguer-Ripolles | ... | Victoria Moreno-Manzano
  • Special Issue
  • - Volume 2017
  • - Article ID 9198328
  • - Research Article

Intra-Articular Injection of Human Synovial Membrane-Derived Mesenchymal Stem Cells in Murine Collagen-Induced Arthritis: Assessment of Immunomodulatory Capacity In Vivo

Minglu Yan | Xin Liu | ... | Yang Li
  • Special Issue
  • - Volume 2017
  • - Article ID 4960831
  • - Research Article

Adipose Tissue-Derived Mesenchymal Stem Cells Have a Heterogenic Cytokine Secretion Profile

Yongkang Wu | Martin J. Hoogduijn | ... | Nicole M. van Besouw
  • Special Issue
  • - Volume 2017
  • - Article ID 1798260
  • - Research Article

Therapeutic Effect and Location of GFP-Labeled Placental Mesenchymal Stem Cells on Hepatic Fibrosis in Rats

Jiong Yu | Guangshu Hao | ... | Hongcui Cao
Stem Cells International
 Journal metrics
Acceptance rate44%
Submission to final decision76 days
Acceptance to publication35 days
CiteScore7.200
Impact Factor3.869
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